Increased serine phosphorylation of insulin receptor substrate-1 (IRS-1) has been observed in several systems to correlate with a decreased ability of the insulin receptor to tyrosine-phosphorylate this endogenous substrate and to inhibit its subsequent association with phosphatidylinositol 3-kinase. In the present studies we have examined the potential role of the mitogen-activated protein (MA...

Phosphatidylinositol turnover is important in intracellular signal transduction in response to various growth factors, hormones and neurotransmitters1}. Transformation by oncogenes such as ras2^, 5rc3), erbB^, fmsb) and fes^ also enhances cellular phosphatidylinositol turnover. Phosphatidylinositol kinase is an enzyme involved in the pathway of phosphatidylinositol turnover. Especially, its act...

One of the leading causes diabetes-related deaths is myocardial damage, which may be cause heart failure in people with type 2 diabetes mellitus. The objective research was to look at impact coronary kind a pair This project aimed explore protective oleanolic acid on damage mellitus and investigate connected mechanism. Specific pathogen free grade db/db male mice were elected as model, while Db...

Evidence is emerging that clozapine can adversely affect immunoglobulin levels. We present a case series of 17 clozapine-treated patients referred to clinical immunology centres in the north west England with otherwise-unexplained hypogammaglobulinaemia. This adds existing evidence and suggests cause clinically significant antibody deficiency will sometimes require specialist intervention. We...

Incubation of isolated hepatocytes with glutamine or proline or in hypotonic media is known to activate glycogen synthase and acetyl-CoA carboxylase as a result of cell swelling. We report here that the same experimental conditions caused an activation of phosphatidylinositol 3-kinase and p70 ribosomal protein S6 kinase (p70 S6 kinase) but did not modify the activity of p42 mitogen-activated pr...

The most common tumor affecting the head and neck is squamous cell carcinoma (HNSCC). characteristics of HNSCC include a rapid onset, lack early diagnosis, drug resistance, relapse systemic adverse effects, leading to inadequate prevention, diagnosis treatment. Notably, previous research suggests that there an association between S100 proteins HNSCC. S100A8, S100A9 S100A14 interfere with prolif...

Although many laboratories have shown that dietary NaCl (salt) intake increases NO production in rodents and humans, the mechanism has not been uncovered. In the present study, pharmacological and dominant-negative strategies were used to show that feeding a formulated diet containing increased amounts of salt to young male Sprague-Dawley rats induced the formation of an endothelial cell-signal...

Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous system. We studied the effects of an Acanthamoeba encephalitis isolate belonging to the T1 genotype on human brain microvascular endothelial cells, ...

Abstract Doxorubicin, sold under the brand name Adriamycin among others, is an important drug for cancer therapy; however, its use limited by cardiotoxicity. Ginsenoside Rg2 extracted from Panax ginseng C.A.Mey., Araliaceae, which believed to have cardioprotective properties. However, date, there been no reports on whether ginsenoside could protect cardiomyocytes against doxorubicin. In this st...