Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described. Common facial features in the three surviving infants include epicanthic folds, a flat nasal bridge, a broad nasal base, anteverted nostrils, a shallow philtrum, and a thin upper lip with a thick lower lip. Ridging of the metopic suture, congenital heart defect, postaxial polydactyly, and hypospad...

A 29-year-old man, suffering from dry skin, who had a brother with rhinoconjunctivitis, was referred to us by a private dermatologist in January 2016 because of erythematous and scaly lips, which had been almost continuously present for >8 years. The eruption had started at both corners of the mouth, but gradually spread to the entire upper and lower lips. At consultation, we also observed eryt...

statement of problem: recognition and determination of facial and dental midline is important in dentistry. currently, there are no verifiable guidelines that direct the choice of specific anatomic landmarks to determine the midline of the face or mouth. objectives: the purpose of this study was to determine which of facial anatomic landmarks is closest to the midline of the face as well as tha...

An 18 month old girl with partial monosomy for the long arm of chromosome 22 is described. The karyotype was 46,XX,del(22)(pter----q13.1::q13.33----qter). To our knowledge this is the first report of monosomy for this specific segment of chromosome 22. Clinical features include developmental delay in all areas, hypotonia, macrosomia, full cheeks, eyebrows, and eyelids, mild epicanthus, wide nas...

We report a case of partial deletion of 9p with partial trisomy of 1q42 syndrome, which is a rare clinical and cytogenetic report. The dysmorphic features of the patient include microcephaly, plagiocephaly, trigonocephaly with metopic ridge, arched eyebrows, hypertelorism, down-slanting palpebral fissure, ptosis, blepharophimosis, unilateral left epicanthic fold, long eyelashes, low-set and pos...

Objectives: The study was designed to investigate the correlation between myofunctional exercises, including repositioning of the tongue onto the palate and changes in intercanine distance of the upper jaw in non-growing patients. Methods: In this retrospective study a total of 141 women and men above the age of 18, treated by the Coulson Institute of Orofacial Myology, with no simultaneous ort...

IMPORTANCE Defects of the central upper lip present a challenge. A variety of techniques have been described, but most tend to efface the natural contours present in the philtrum and the cutaneous-mucosal vermilion border (Cupid's bow). Furthermore, the techniques typically require a second-stage procedure to improve the upper lip aesthetic. We discuss a novel technique using bilateral transpos...