Thioureas are oxygenated by flavin-containing monooxygenases (FMOs), forming reactive sulfenic and/or sulfinic acids. Sulfenic acids can reversibly react with GSH and drive oxidative stress through a redox cycle. For this reason, thiourea S-oxygenation is an example of FMO-dependent bioactivation of a xenobiotic. Functional FMO2 is expressed in the lung of 26% of individuals of African descent ...

The black pigment cells in the skin, iris, and retina of Eleutherodactylus martinicensis (Tschudi) are melanophores. Under the influence of c o 1 per cent, phenylthiourea the melanin disappears in about 84 hours at laboratory temperatures. After administration of the substance for 5 days, discontinuance of treatment is followed by return of the pigment within 72 hours, to an extent at least equ...

an efficient synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives via simple three-component reaction and one-pot reactions between isoquinoline, dimethyl acetylenedicarboxylate and n-phenylthiourea under solvent-free conditions without using any additional catalyst, is described. the mild reaction conditions and good yields and exhibit the synthetic a...

OBJECTIVE The inability to taste phenylthiocarbamide (PTC) has been associated with medical and neurological illnesses not typically related to taste. The authors examined PTC sensitivity in schizophrenia patients and their non-ill relatives to determine whether this represented a vulnerability marker. METHOD PTC sensitivity was assessed in 42 schizophrenia patients, 23 healthy comparison sub...

Past research associating phenylthiocarbamide/propylthiouracil (PTC/PROP) taste status with alcoholism has produced equivocal results. Some have found higher proportions of nontasters among those with a family history of alcoholism than controls, whereas others have not. The purpose of this study was to investigate the relationship between PTC taste status, alcohol problems, and family history ...