The influences of ?-? interactions in phycocyanin proteins and their environmental preferences were analyzed. observations indicate that the majority aromatic residues are involved interactions. Phenylalanine (Phe) tyrosine (Tyr) found to be ??? much more frequently than tryptophan (Trp) or histidine (His). Similarly, Phe-Phe Tyr-Tyr interacting pair had highest frequency occurrence. In additio...

Phenylketonuria (PKU) (OMIM1 261600) is one of the most common congenital metabolic disorders. The phenylalanine (Phe) hydroxylase enzyme needed to break down phenylalanine exhibits significantly reduced activity as a result of mutations in the encoding gene. Untreated, it causes severe psychomotor retardation. Only thanks to early diagnosis as part of newborn screening and immediate commenceme...

The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH active site, but also an allosteric ligand that increases enzyme activity. Phe has been proposed to ...

Abstract The stability constants of some the binary and ternary system involving Nickel(II) have been studied. Bis-(pyridyl) benzilidene acts as a primary ligand. Glycine, L-alanine, L-phenylalanine, L-leucine L-valine were secondary complex are calculated by SCOGS computer program. reported values ± 0.02 log unit accuracy. protonation increase with an increasing percentage dimethyl sulphoxide....

BACKGROUND Phenylketonuria (PKU) is caused by the inherited defect of the phenylalanine hydroxylase enzyme, which converts phenylalanine (Phe) into tyrosine (Tyr). Neonatal screening programs and early treatment have radically changed the natural history of PKU. Nevertheless, an increased risk of neurocognitive and psychiatric problems in adulthood remains a challenging aspect of the disease. I...

Removal of base Y adjacent to the anticodon of yeast phenylalanine tRNA changes the coding properties of tRNAPhe. Phenylalanine tRNA from which base Y has been removed (tRNA:b,“) recognizes UUC better than WU. Codon UUU is read efficiently at higher Mg++ concentration or in the presence of streptomycin. A dipeptide cannot be synthesized with N-acetyl-Phe-tRNAPh” and Phe-tRNA% unless the base Y ...

The complete nucleotide sequence of wheat germ phenylalanine transfer RNA (tRNA(Phe)) is presented. This RNA, which is an acceptable substrate for yeast phenylalanine tRNA synthetase, has a structure very similar to that of yeast tRNA(Phe). Only 16 of the 76 nucleotides are different, and all but two of the nucleotide changes are located in regions that are doublestranded in the cloverleaf mode...

Objective(s):Phenylketonuria (PKU) is a genetic inborn error of phenylalanine (Phe) metabolism resulting from insufficiency in the hepatic enzyme, phenylalanine hydroxylase (PAH), which leads to elevated levels of Phe in the blood. The present study was carried out for mutation analysis of the PAH gene in West Azerbaijan province of Iran. Materials and Methods:A total of 218 alleles from 40 PKU...

In untreated phenylketonuria (PKU), deficiency of phenylalanine hydroxylase (PAH) results in elevated blood phenylalanine (Phe) concentrations and severe mental retardation. Current dietary treatment prevents mental retardation, but cognitive outcome remains suboptimal. The mechanisms by which elevated blood Phe concentrations disturb cerebral metabolism and cognitive function have not been ful...

The electrical conductivity via peptide networks was measured using conductive probe atomic force microscopy, where the tryptophan-containing peptide network (composed of Phe-Trp dipeptides) exhibited a superior (5 fold) conductivity in comparison to an all phenylalanine network (composed of Phe-Phe dipeptides). These results are in line with previous spectroscopic measurements exploring intram...