Abstract β-thalassemia major (β –TM) is the most common thalassemia severe phenotype among Iranians. In recent years, molecular understanding of pathogenesis of β –TM has provided a great opportunity regarding diagnostic issues. Creating comprehensive molecular databases provides highly sensitive diagnostic tools for β –TM and effective prenatal diagno...

introduction lori sheep is one of the most important breeds in iran that is mostly bred in lorestan province, north-east of khuzestan and some areas of ilam provinces. the name of this breed is derived from lori tribe, which is one of the major nomadic groups of zagros mountain in western areas of iran. lori sheep is resistant to mountain conditions and hot and dry plains. this sheep breed has ...

abstract β-thalassemia major (β –tm) is the most common thalassemia severe phenotype among iranians. in recent years, molecular understanding of pathogenesis of β –tm has provided a great opportunity regarding diagnostic issues. creating comprehensive molecular databases provides highly sensitive diagnostic tools for β –tm and effective prenatal diagnosis (pnd) molecular screening tests. despit...

it is clear that colorectal cancer (crc) develops through multiple genetic and epigenetic pathways. these pathways may be determined on the basis of three molecular features: (i) mutations in dna mismatch repair genes, leading to a dna microsatellite instability (msi) phenotype, (ii) mutations in apc and other genes that activate wnt pathway, characterized by chromosomal instability (cin) pheno...

the aim of the present study was to estimate the genetic parameters and genetic trends of somatic cell score (scs) in the first 3 lactations of iranian holstein cows by random regression (rr) animal model by using restricted maximum likelihood (reml) method. the data set used in this analysis included observations of 340318 test-day records of 41526 cows in 288 herds; 89969 test-day of 11750 co...

the present study was conducted to estimate genetic parameters and genetic, environmental and phenotypic trends of milk production traits in holstein cattle of hamedan province. in this study 11986 305-d records of first three parities of hamedan province holstein cattle, which were gathered during 1990-2011, were used. variance-covariance components and breeding values were estimated using ani...

the molecular mechanisms of the fact that more than 50% of the individuals with the same genetic make up (e.g. identical twins in schizophrenia) do not show the same psychiatric phenotype remained undefined in psychiatry. this along with the failure to find responsible genes with major effects in psychiatric disorders and lack of consistency of genetic association studies led to the current una...

abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...

The aim of the present study was to estimate the genetic parameters and genetic trends of somatic cell score (SCS) in the first 3 lactations of Iranian Holstein cows by random regression (RR) animal model by using Restricted Maximum Likelihood (REML) method. The data set used in this analysis included observations of 340318 test-day records of 41526 cows in 288 herds; 89969 test-day of 11750 co...