BACKGROUND AND OBJECTIVES To review phase II and phase III treatments of symptomatic uterine fibroids (myomas) using laparoscopic radiofrequency volumetric thermal ablation (RFVTA). METHODS We performed a retrospective, multicenter clinical analysis of 206 consecutive cases of ultrasound-guided laparoscopic RFVTA of symptomatic myomas conducted on an outpatient basis under two phase II studie...

Background: A wide range of preventive medications for migraine attacks, with varying efficacy is currently in use. Studies comparing the efficacies of these drugs would be of value in the proper treatment of the disease. The present study compared the frequency, duration and intensity of migraine attacks during and following treatment with cyproheptadine (4 mg, twice daily) or Blellergal (bell...

BACKGROUND Clinical research and drug development in orphan diseases are challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug-approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. METHODS A Bayesian m...

the pre.sent rep.or,t describes the morphological and if nod h pron erative aspects of lymph es iii odgkin s disease grown in tissue culture. the development of hodgkin's lymph-nodes grown in vitro seems to depend upon the  a~e of t~e person and the stage of the hodgkin's disease at the time the i h is obtained. ymp - the morphological and the proliferative aspects ('helralcterizi~d of hodgkin'...