The interest on personalized medicine encourages researches pharmacogenetics. promotion of new analytical combinations in extensive drug development and also with the progression technologies for human gene cloning resulted a great In last years genetical sciences influenced Personalized includes areas such as stratified precision these terms are closely related Moderate response rates differen...

MOTIVATION The information model chosen to store biological data affects the types of queries possible, database performance, and difficulty in updating that information model. Genetic sequence data for pharmacogenetics studies can be complex, and the best information model to use may change over time. As experimental and analytical methods change, and as biological knowledge advances, the data...

Personalized medicine is playing an ever-increasing role in patient care. Over the past decade, awareness of the role of pharmacogenetics and its benefits is leading to its growing acceptance among providers. Though providers are using pharmacogenetics in practice, the decision-making process of when to use this tool can be ambiguous. Herein, we propose an algorithm to help guide providers on w...

Pharmacogenetics is a scientific discipline that examines the genetic basis for individual variations in response to therapeutics. Pharmacogenetics promises to develop individualized medicines tailored to patients’ genotypes. However, identifying and genotyping a vast number of genetic polymorphisms in large populations also pose a great challenge. This article will address the recent technolog...

personalized medicine aims is to supply the proper drug to the proper patient within the right dose. pharmacogenomics (pgx) is to recognize genetic variants that may influence drug efficacy and toxicity. all things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient gene...

Most of the literature on pharmacogenetics assumes that the main problems in implementing the technology will be institutional ones (due to funding or regulation) and that although it involves genetic testing, the ethical issues involved in pharmacogenetics are different from, even less than, 'traditional' genetic testing. Very little attention has been paid to how clinicians will accept this t...

Approximately 60 years ago, the metabolism and disposition of isoniazid, an antituberculosis drug, was one of the earliest demonstrations of pharmacogenetic differences in drug handling that resulted in clinical consequences.2 There were marked differences in excretion of the drug among individuals who were then classified into slow acetylators (SA) and rapid acetylators of isoniazid with SA in...

EDITORIAL article Front. Pharmacol., 08 August 2023Sec. Pharmacogenetics and Pharmacogenomics Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1267344

Allergic diseases such as bronchial asthma and atopic dermatitis develop by a combination of genetic and environmental factors. Several candidate causative genes of asthma and atopy have been reported as the genetic factors. The clinical features of patients and causes of diseases vary. Therefore, personalized medicine (tailor-made medicine) is necessary for the improvement of quality of life (...