Bacterial-based therapies are emerging as effective cancer treatments and hold promise for refractory neoplasms, such as pancreatic ductal adenocarcinoma (PDAC), which has not shown significant improvement in therapy for more than 25 years. Using a novel combination of shIDO-ST, a Salmonella-based therapy targeting the immunosuppressive molecule indoleamine 2,3-dioxygenase (IDO), with an enzyme...

In this issue of RESPIRATORY CARE, Van de Louw et al1 describe the magnitude of spurious hypoxemia as suggested by arterial blood gases (ABGs) obtained from subjects with acute leukemia and hyperleukocytosis. Spurious hypoxemia, commonly known as leukocyte larceny, is just one of several erroneous values or discrepancies with pulse oximetry and the bedside assessment (or bioassay) that may occu...

1008 Saturday June 3, 1:15 PM to 4:15 PM; Hall D1 Ian Flinn, Richard van der Jagt, Julie E. Chang, Peter Wood, Tim E. Hawkins, David MacDonald, Judith Trotman, David Simpson, Kathryn S. Kolibaba, Samar Issa, Doreen M. Hallman, Ling Chen, John M. Burke. First-line treatment of iNHL or MCL patients with BR or R-CHOP/R-CVP: Results of the BRIGHT 5-year follow-up study. USOR Study # 7152 Abstract #...

Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated in pancreatic cancer growth and the tumor microenvironment. Overexpression of HAS3 increased hyaluronan synthesis in BxPC-3 pancreatic cancer cells. In vivo, overexpression of HAS3 led to faster growing xenograft tumors with abundant extra...