Lack of physical activity results in muscle atrophy and bone loss, which can be counteracted by mechanical loading. Similar molecular signaling pathways are involved in the adaptation of muscle and bone mass to mechanical loading. Whether anabolic and metabolic factors regulating muscle mass, i.e. insulin-like-growth factors-I (IGF-I Ea), mechano-growth factor (MGF), myostatin, vascular endothe...

To explore the impact of global incorporation of fluorinated aromatic amino acids on protein function, we investigated the effects of three monofluorinated phenylalanine analogs para-fluorophenylalanine (pFF), meta-fluorophenylalanine (mFF), and ortho-fluorophenylalanine (oFF) on the stability and enzymatic activity of the histone acetyltransferase (HAT), tGCN5. We selected this set of fluorina...

Malnutrition, in particular protein-energy malnutrition, is a highly prevalent condition older adults, and associated with low muscle mass function, increased prevalence of physical frailty. Malnutrition often exacerbated the residential care setting due to factors including lack dentition appetite, dementia dysphagia. This review aims provide an overview available literature adults regarding f...

We have previously indicated that porcine blastocysts can be produced by in vitro fertilization (IVF) and culture (IVC) in chemically defined porcine gamete medium (PGM) and porcine zygote medium (PZM)-5, respectively, In the present study, the effects of basic media and macromolecular components on in vitro maturation (IVM) were investigated to develop a defined system for in vitro embryo prod...

Abstract A novel particle filter proposed recently, the flow (PFF), avoids long‐existing weight degeneracy problem in filters and, therefore, has great potential to be applied high‐dimensional systems. The PFF adopts idea of a flow, which sequentially pushes particles from prior posterior distribution, without changing each particle. essence is that it assumes embedded reproducing kernel Hilber...

Abstract Aim Periprosthetic femur fractures (PFF) are becoming increasingly frequent due to an ageing population and growing number of arthroplasties. PFF revision surgery is associated with significant peri-operative blood loss higher transfusion requirements. There few strategies reduce rates transfusion. One which the use cell-salvage. The aim this study was determine whether cell salvage sh...

BACKGROUND Patients with proximal femoral fracture (PFF) are at high risk of postoperative complications. Goal-directed haemodynamic treatment (GDHT) in other high-risk surgical patients reduces postoperative complications. We aimed to compare effects of GDHT and routine fluid treatment (RFT) on postoperative outcomes after PFF surgery. METHODS PFF patients (≥70 yr) were enrolled in this sing...

The objective of this study was to evaluate the feasibility of preserving porcine oocytes without freezing. To optimize preservation conditions, porcine cumulus-oocyte complexes (COCs) were preserved in TCM-199, porcine follicular fluid (pFF) and FCS at different temperatures (4°C, 20°C, 25°C, 27.5°C, 30°C and 38.5°C) for 1 day, 2 days or 3 days. After preservation, oocyte morphology, germinal ...