For analysis of in vivo dopamine receptor binding in the rat brain by positron emission tomography (PET), a convenient method to obtain precise anatomical registration for striatum and cerebellum on the PET image was developed. On the PET measurements, a control, an anesthetized rat was positioned in a stereotaxic holder so that the horizontal plane of the PET image would be parallel to the hor...

AIM Evaluate the diagnostic accuracy of 68Ga-labeled HBED-CC-PSMA-PET/MRI for detection of recurrent PCa in comparison to PET/CT. METHODS 48 patients with suspected recurrent PCa underwent PET/CT after injection of the 68Ga-HBED-CC-PSMA ligand followed by integrated PET/MRI. Image analysis was performed by nuclear medicine physicians and radiologists with respect to the detection of lymph nod...

Positron emission tomography (PET) imaging can provide quantitative physiological information, in addition to qualitative information. However, most of PET image handling software packages have not included modeling and quantitative analysis functions. In this paper, based on some of our systematic studies on biomedical functional image data processing and modeling, we developed a functional im...

GE Healthcare, Waukesha, USA A new ToF-PET/MR scanner has recently been deployed at the University Hospital of Zurich for clinical evaluation purposes. The goal of the present work was to compare the image quality obtained on this system with that of equivalent state-of-the-art standalone scanners. The GE Signa PET/MR is a whole-body scanner combining a 3T wide-bore MR system with a 25 cm PET d...

To evaluate the quality and diagnostic performance of F-Fluoride positron-emission tomography/magnetic resonance imaging (F-Fluoride PET/MR) compared to F-Fluoride positron-emission tomography/computed tomography (F-Fluoride PET/CT) imaging in patients with unclear foot pain. Methods: Twenty-two patients (9 men, 13 women; mean age 48±18 years, range: 20–78 years) were prospectively included in ...

GE Healthcare, USA In a functional PET/MR study, it is difficult to get good temporal resolution of activity distribution from PET images because of the need to image for a certain length of time to get sufficient count statistics (image SNR). Time-of-flight (TOF) reconstruction can be used to increase PET images SNR and therefore increase the temporal resolution. Five patients were injected wi...

A novel dynamic (4D) PET to PET image registration procedure is proposed and applied to multiple PET scans acquired with the high resolution research tomograph (HRRT), the highest resolution human brain PET scanner available in the world. By extending the recent diffeomorphic log-demons (DLD) method and applying it to multiple dynamic [11C]raclopride scans from the HRRT, an important step towar...

The purpose of this study is to systematically evaluate the usefulness of Positron emission tomography/Magnetic resonance imaging (PET/MRI) images in a clinical setting by assessing the image quality of Positron emission tomography (PET) images using a three-segment MR attenuation correction (MRAC) versus the standard CT attenuation correction (CTAC). We prospectively studied 48 patients who ha...