Macrolides, a class of antimicrobials isolated from Streptomycetes more than 50 years ago, are used extensively to treat sinopulmonary infections in humans. In addition, a growing body of experimental and clinical evidence indicates that long-term (years), low (sub-antimicrobial)-dose 14- and 15-membered ring macrolide antibiotics, such as erythromycin, clarithromycin, roxithromycin and azithro...

The spores of Bacillus spp. are found widely distributed in nature, which may cause contamination of the environment and eventually diseases to humans and animals. The formation of the bacterial spore is a sophisticated mechanism by which some bacteria remain viable inadequate when subjected to survival stress such as lack of nutrients. The spores are highly resistant to heat, radiation, variou...

This study describes a rapid, cost-effective pre-clinical method to screen for pro- or antiarrhythmic effects of substances in an isolated heart preparation in line with the regulatory requirements of ICHS7B. The computational method "MFC method" quantifies arrhythmic episodes from isolated perfused hearts based on measuring the variation in the maximum force of contraction. Experiments were pe...

ferula persica, is the well-known species of the genus ferula in iran and has two varieties: persica and latisecta. they have both been extensively used in traditional medicine for a wide range of ailments. a great number of chemical compounds including sesquiterpene coumarins and polysulfides have been isolated from this plant. fresh plant materials, crude extracts and isolated components of f...

background and purpose: multiple sclerosis (ms) is believed to be an immune-mediated disorder that develops from an interaction of the individual's genetic and as yet unidentified environmental causes. the prevalence of auto-antibodies in multiple sclerosis patients and their clinical associations vary in various studies. the aim of this study was to determine serum auto antibodies in multiple ...

The anisotropy parameter of two-dimensional equilibrium clusters of site percolation process in long-range self-affine correlated structures are studied numerically. We use a fractional Brownian Motion(FBM) statistic to produce both persistent and anti-persistent long-range correlations in 2-D models. It is seen that self affinity makes the shape of percolation clusters slightly more isotropic....

To determine the role of von Willebrand factor (vWF) in adhesion of sickle (SS) erythrocytes in microvascular flow conditions, we have perfused the ex vivo mesocecum vasculature of the rat with desmopressin, an analogue of vasopressin that causes the release of endothelial vWF. Analysis of vWF in the venous effluent of the isolated vasculature showed mainly the presence of extra-large molecular...

Citation: Vetreno RP, Lawrimore CJ, Rowsey PJ and Crews FT (2018) Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin. Front. Neurosci. 12:200. doi: 10.3389/fnins.2018.00200 Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolesc...