Pigmented purpuric dermatoses (PPD) are a group of disorders which have histopathologically similar but morphologically different appearance. The five main clinical subtypes of PPD has been described. The perivascular lymphocytic infiltration of superficial dermal vessels with extravasations of red blood cells are common histopathological characteristics for all types of PPD. The etiopathogenes...

The chemokine receptor CCR7 regulates lymphocyte trafficking, and CCR7 deficiency induces infiltration of T and B cells adjacent to vessels in mouse lungs. Perivascular infiltration of T and B cells has also been found in human pulmonary arterial hypertension, and downregulation of the CCR7 receptor in circulating leukocytes of such patients has been observed. To investigate whether changes in ...

Intranasal inoculation of type 5 adenovirus (Ad5) produced pneumonia in mice even though the virus did not replicate. To induce the pneumonia, however, a large viral infectious dose was required--i.e., 10(10) plaque-forming units. Four strains of inbred mouse were studied (C57BL/6N, C57BL/10ScN, CBA/N, and C3H/N): all showed similar inflammatory responses, although the greatest infiltration occ...

Churg–Strauss syndrome (CSS) is a form of small and medium vessel vasculitis characterized by eosinophilic infiltration of organs with necrotizing vasculitis and interstitial and perivascular granulomas. Three phases have been described in the natural history of the disease (prodromal, eosinophilic, and vasculitic phases) although they do not always occur successively. Initial records show CSS ...

Key points • Melkersson-Rosenthal syndrome should be suspected in cases of recurrent facial palsy associated with swelling of orofacial structures and/or a furrowed tongue. • Biopsy of suggestive lesions typically reveals noncaseating granulomas with perivascular and lymphatic inflammatory cell infiltration. • The pathophysiology involves an immunologically mediated inflammatory response. • Tre...

We report a 46-year-old woman with primary biliary cirrhosis (PBC) presenting with Sjögren's syndrome and systemic mononuclear inflammatory vasculopathy. Biopsy specimens of sural nerve showed findings consistent with vasculitic neuropathy. Perivascular inflammatory mononuclear cell infiltration was observed on muscle biopsy specimen. The findings of abdominal computed tomography and brain magn...

Histopathological alterations in kidneys have been studied in squirrels with repeated intraperitoneal injections of cadmium acetate at a dose of 1.0 mg Cd/Kg of body weight. Cloudy swelling, necrosis, denudation and destruction of tubular epithelium, focal aggregates of inflammatory cells, perivascular inflammation by chronic inflammatory cells and perinephric haemorrhage with infiltration by p...

The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68(+)GR1(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the end...

Acute generalized exanthematous pustulosis is a rare drug-induced eruption that characterized by sterile non-follicular pustules arising on an often edematous diffuse erythematous background. Generalized pustular psoriasis acute and severe clinical form of presenting as with base. Differentiating both diseases challenging because their histopathological similarities. A 62-year-old woman present...

Aim. The study is aimed at describing pancreatic islets as one of the SARS-CoV-2 targets. Materials and methods. object was pancreas. involved histological staining. Results discussion. autopsy revealed signs typical bilateral viral interstitial pneumonia. Histological examination alveoli with disatelectasis, intra-alveolar edema, hyaline membranes in a part alveoli. pancreas showed hemorrhages...