The effects of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on multidrug resistance in tumor cells were investigated. Protein kinase-inhibitory activity of NA-382 was lower but more selective to Ca2+/phospholipid-dependent protein kinase than that of staurosporine. NA-382 at noncytotoxic concentrations effectively reversed in vitro multidrug resistance of Adriamy...

Background: Untreated maternal phenylketonuria or hyperphenylalaninemia may result in nonphenylketonuric offspring with neonatal sequelae, especially intellectual disability, microcephaly, and congenital heart disease (CHD). Dietary treatment to control phenylalanine concentrations can prevent these sequelae. Objective: We aimed to present an overview of reported pregnancy complications and neo...

Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian cancer tissues and cell lines. miR‑382 inhibited ovarian cancer cell prolifera...

382 yak cows were examined for milk yield, fat, protein and lactose contents. Six polymorphic loci, alphas1-CN, kappa-CN, beta-CN, beta-Lg, alpha-La and MUC-1, were scored by PAGE electrophoresis for each individual. The values of milk yield, fat, protein and lactose content were 247.13 kg, 5.81%, 5.18% and 4.93%, respectively. Based on the 6 polymorphism loci, the average heterozygosity of the...

Introduction. Pastures are the primary source of food in livestock systems and can be a suitable niche for insects with beneficial harmful functions. Objective. To estimate entomofauna associated three species pastures, Cenchrus ciliaris, Chloris gayana, Megathyrsus maximus, conditions Colombian Caribbean. Materials methods. Ten samplings were carried out two contrasting periods (August to Octo...

ABSTRACT A light sphagnum peat mix inoculated with Trichoderma hamatum 382 consistently provided a significant (P = 0.05) degree of protection against bacterial spot of tomato and its pathogen Xanthomonas euvesicatoria 110c compared with the control peat mix, even though this biocontrol agent did not colonize aboveground plant parts. To gain insight into the mechanism by which T. hamatum 382 in...

Anopiophora glabripennis (Motsch.) (Coleoptera: Cerambycidae) is a destructive woodborer, attacking many species of deciduous hardwood trees. Apriona swainsoni (Hope) (Coleoptera: Cerambycidae) is a woodborer of Sophora japonica L. (Angiospermae: Fabaceae). Dastarcus helophoroides (Fairmaire) (Coleoptera: Bothrideridae) is an important natural enemy of both Cerambycid species in China. Kairomon...

Hylastes spp. (Coleoptera: Scolytidae) were evaluated as potential vectors of Leptographium spp. fungi. Bark beetles were trapped from stands ofloblolly pine, Pinus taeda L., exhibiting a range of decline symptoms in central Alabama. Under controlled conditions, field-collected adult Hylastes salebrosus Eichoff (Coleoptera: Scolytidae) and Hylastes tenuis Eichoff (Coleoptera: Scolytidae), which...