The purpose of this note is to posit and discuss the concept of "competitive inhibition potential" (CIP), which is an in vivo index of the ability of a competitive inhibitor to elevate plasma concentrations of drug substrates, when the competitive inhibitor is administered at its usual and customary dose.

Quantitative scaling into percent signal change is helpful to detect and eliminate “bad” results with abnormal extreme values. While cognitive effects give signal changes on the order of 1% (and larger in the visual and auditory cortices), signal variations of over 10% may arise from motion and other artifacts in the data. Thus, a quantitative check on measured effect size can be used to screen...