Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

The coordination of 2-pyridyltetrazolate and ortho-xylene-linked bis(NHC)cyclophane to Pt(II) yielded a novel complex characterised by enhanced pure deep-blue emission, whose intensity can be modulated via methylation of the tetrazole ring.

methanesulfonic acid (msa) was found to be an efficient catalyst for the synthesis of 1-substituted-1h-1,2,3,4-tetrazoles. a series of 1-substituted tetrazole compounds were synthesized from the reaction of various primary amines, sodium azide and triethyl orthoformate in the presence of catalytic amounts of msa at room temperature. in this protocol, some of the tetrazole derivatives were synth...

ABSTRACT A series of new benzimidazole and benzotriazole derivatives containing a tetrazole moiety was synthesized by N-alkylation of 5-aryltetrazole with 4,5,6,7-tetrabromo-1-(3-chloropropyl)-1H-benzimidazole and 4,5,6,7-tetrabromo-2-(3-chloropropyl)-2H-benzotriazole. The reaction was regioselective and mostly 2,5-disubstituted tetrazole derivatives were obtained. The effect of all synthesized...

We report a chemical lipidation model for the study of protein lipidations in vitro and in live mammalian cells based on a bioorthogonal, photoinduced tetrazole-alkene cycloaddition reaction.

An adaptive tetrazole-derived host provides insight into tetrazolate-biomolecule interactions, and is the first member of a new family of receptors that function in pure water.

Highly purified 5-vinyl-1H-tetrazole was synthesized, which is in great demand modern medicine and industry as a monomer for obtaining nitrogen-rich macromolecular compounds reagent the complete synthesis of biological compounds. The molecular structure studied experimentally with sequential X-ray diffraction analysis theoretically ab initio quantum chemical calculations. data from differential...