the new phase-ii n-glucoside metabolites of butobarbitone and pentobarbitone are identified and quantified in human urine after single doses of these drugs. the identification and quantification of these metabolites were carried out by mass spectroscopy technique (accurate mass measurement and high voltage scanning). it was found that the butobarbitone n-glucoside comprised 26% of the dose with...

In the cat, the e.e.g. of the neocortex and the hippocampus and the cortical evoked potentials to central sensory pathway stimulation seen during Althesin anaesthesia were compared with those seen during barbiturate anaesthesia. During Althesin anaesthesia the neocortical e.e.g. displayed spindle-like activity, which was similar to that seen during barbiturate anaesthesia. Although both Althesi...

A rapid gas-chromatographic method has been developed for the determination of butobarbitone, amylobarbitone, hexabarbitone, pentobarbitone, quinalbarbitone, phenobarbitone glutethimide, and methaqualone in ;finger-prick' samples of plasma. This has been applied to the analysis of some of these drugs in plasma taken from patients after therapeutic dosage and over-dosage.

In rabbits which were ventilated mechanically, with a background anaesthetic of pentobarbitone or after decerebration, ketamine depressed preganglionic sympathetic activity and arterial pressure. Conduction through central baroreceptor pathways, tested by depressor nerve stimulation, showed a selective inhibition of the heart rate response.

Alcoholic and chloroform extracts of E. albaT. purpurea and B. diffusa were screened for antihepatotoxic activity. The extracts were given after the liver was damaged with CCl4. Liver function was assessed based on liver to boy weight ratio, pentobarbitone sleep time, serum levels of transaminase (SGPT, SGOT), alkaline phosphatase (SALP) and bilirubin. Alcoholic extract of E. alba was found to ...

Background: The present study was planned to investigate the effect of Qurse Rewand commonly used compound hepatoprotective drug on sleep duration in sodium pentobarbital (PB)-induced sleeping in mice. Methodology: The animals were divided into five groups of 6 animals each and they were fasted overnight. The animals of group I and II were left untreated, whereas the animals kept in group III, ...

Despite its explosive properties and toxicity to both animals and humans, diethyl ether is an agent long used in Japan in the anaesthesia jar method of rat anaesthetises. However, in response to a recent report from the Science Council of Japan condemning diethyl ether as acceptable practice, we searched for an alternative rat anaesthesia method that provided data continuous with pre-existing r...

1 Radioligand binding and patch-clamp techniques were used to study the actions of g-aminobutyric acid (GABA) and the general anaesthetics propofol (2,6-diisopropylphenol), pentobarbitone and 5a-pregnan3a-ol-20-one on rat a1 and b3 GABAA receptor subunits, expressed either alone or in combination. 2 Membranes from HEK293 cells after transfection with a1 cDNA did not bind signi®cant levels of [S...