نتایج جستجو برای: pentobarbital

تعداد نتایج: 2674  

Journal: :Journal of clinical pharmacology 1980
D J Weidler N S Jallad K L Black J G Wagner

The values of the pharmacokinetic parameters for pentobarbital were determined in 18 cats, 12 of which were subjected to acute ischemic stroke by ligation of the left middle cerebral artery (LMCA). All 18 ats received 50 mg/kg sodium pentobarbital during operation. The following three experimental groups were formed: control (sham-operated); ischemic stroke plus administration of 4 mg/kg dexame...

Journal: :The Journal of surgical research 1984
A Kazmers W M Whitehouse G B Zelenock J L Cronenwett S M Lindenauer J C Stanley

Vasoactive effects of supplemental pentobarbital anesthesia in the canine hindlimb microcirculation were documented in two groups of animals previously anesthetized with 30 mg/kg pentobarbital: Group I with a 5 mg/kg intravenous (iv) bolus of pentobarbital (n = 8) and Group II with a 5 mg/kg 2-min iv infusion of pentobarbital (n = 7). In Group I, measurements at baseline (BL) and 5, 15, 20, and...

Journal: :iranian red crescent medical journal 0
vahid reza askari faculty of pharmacy, mashhad university of medical sciences, mashhad, ir iran vafa baradaran rahimi faculty of pharmacy, mashhad university of medical sciences, mashhad, ir iran ahmad ghorbani pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, ir iran hassan rakhshandeh pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, ir iran; department of pharmacology, school of medicine, mashhad university of medical sciences, mashhad, ir iran; pharmacological research center of medicinal plants, faculty of medicine, mashhad university of medical sciences, mashhad, ir iran. tel: +98-5138828566, fax: +98-5138828567

background sleep disorders are accompanied by several complications, and currently used soporific drugs can induce unwanted effects such as psychomotor impairment, tolerance, amnesia, and rebound insomnia. results hae increased the duration of pentobarbital-induced sleep at doses of 25, 50, and 100 mg/kg (p < 0.001). the hypnotic effect of hae was comparable to that induced by diazepam. similar...

Journal: :The Journal of General Physiology 1997
James P. Dilger Rebecca Boguslavsky Martin Barann Tamir Katz Ana Maria Vidal

We used patch clamp techniques to study the inhibitory effects of pentobarbital and barbital on nicotinic acetylcholine receptor channels from BC3H-1 cells. Single channel recording from outside-out patches reveals that both drugs cause acetylcholine-activated channel events to occur in bursts. The mean duration of gaps within bursts in 2 ms for 0.1 mM pentobarbital and 0.05 ms for 1 mM barbita...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
J J Rady W Lin J M Fujimoto

Pentobarbital administered intracerebroventricularly to mice has been shown previously to inhibit the analgesic action of morphine given intrathecally. The purpose of the present study was to examine the proposal that this antianalgesic action was mediated spinally by cholecystokinin. First, intrathecal coadministration of cholecystokinin-B sulfate (CCK8s) with morphine inhibited the analgesic ...

Journal: :Vision Research 1999
Natalia V Kapousta-Bruneau

Photovoltages, the fast P3(t) component of electroretinogram (ERG), were registered between two microelectrodes across the rod outer segments. The P2(t) component, obtained by subtracting the ERGs measured before the application of 50 microM APB from those measured after the application of 50 microM APB, was used as an indicator of depolarizing bipolar cell activity. Measurements of the scotopi...

2004
H. PORTER J. B. LANGSTON

201(5): 897-900. I g6 I .-Dogs under chloralose anesthesia show augmented reflex responses of systolic arterial pressure, mean arterial pressure, diastolic arterial pressure, and pulse rate to bilateral occlusion of the common carotid arteries over the responses of these same parameters before any a nesthesia. H yporeflexia, as indicated by these parameters, is observed when the anesthetic is c...

H Rakhshandah K Dolati M Hosseini

Rosa damascena (Rosaceae) has been found to act on central nervous system including the brain. Several studies confirm that Rosa damascena inhibits the reactivity of the hypothalamus and pituitary systems in rat and can suppress the reactivity of central nervous system. In traditional medicine the hypnotic effect of rose is also suggested. In the present study hypnotic effect of ethanolic, aque...

Journal: :Brain research bulletin 1991
F C Chang

Respiratory effects of sodium pentobarbital (35 mg/kg; IP) were studied in guinea pigs chronically instrumented to permit concurrent recordings of bulbar respiratory-related units (RRUs), diaphragmatic electromyogram (DEMG), and electrocorticogram (ECoG). RRU activities were recorded from either the Bötzinger Complex (BOT; expiratory) or Nucleus para-Ambiguus (NpA; inspiratory). Pentobarbital-i...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
J K Rowlett W L Woolverton

The present study compared the discriminative stimulus effects of the imidazopyridine, zolpidem, with a triazolobenzodiazepine, triazolam, in pentobarbital-trained rhesus monkeys and rats. Rhesus monkeys (n = 4), trained to discriminate pentobarbital (10 mg/kg intragastric [i.g.]) from saline under a FR 1 discrete-trials shock avoidance procedure, were given zolpidem (0.10-30 mg/kg i.g.) or tri...

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