The " discovery " of penicillin by Fleming in 1928 and its dramatic production, urged on by the necessities of war, heralded a new era of therapeutics. It has changed the pattern of disease the prognosis of infections, the expectation of life, indeed, it has changed the whole human ecology. Before the discovery of penicillin, there were many early descriptions of the characteristics and propert...

Fungi involved in the biodegradation of maizecob were isolated and screened for cellulase activity using glucose and carboxylmethyl cellulose as carbon sources. The effect of the carbon sources on cellulase production was determined. Eleven fungi species were isolated which include Rhizopus oryzae, Aspergillus flavus, Mucor racemosus, Aspergillus niger, Penicillium atrovenetum, Penicillium expa...

Infections caused by Penicillium species are rare in dogs, and the prognosis in these cases is poor. An unknown species of Penicillium was isolated from a bone lesion in a young dog with osteomyelitis of the right ilium. Extensive diagnostic evaluation did not reveal evidence of dissemination. Resolution of lameness and clinical stability of disease were achieved with intravenous phospholipid-c...

Despite several studies reporting Penicillium as one of the most frequent fungal genera in cork planks, the isolates were rarely identified to species level. We conducted a detailed study to identify Penicillium species from the field to the factory environment prior to and after boiling the cork planks. A total of 84 samples were analyzed. Of the 486 Penicillium isolates phenotypically identif...

Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Received for publication: February 14, 2008. Reprint request: Prof. Dr. Nongnuch Vanittanakom, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Email: [email protected] Keyword: Penicillium marneffei, Penicillium citrinum, phagocytosis, killin...

Penicillium and Aspergillus have been recognized as important aeroallergens for more than 30 years, and are especially significant in indoor environments. There are over 400 species of Penicillium and Aspergillus combined, but there is little information on which species occur most frequently in the environment, or if each exhibits unique allergenic properties. A preliminary study showed no ove...

An isolate of Penicillium biforme Thom produced rugulovasines A and B. An isolate of Penicillium rubrum Stoll produced rugulovasines A and B and also chlororugulovasines A and B. Both fungi represent new sources of the rugulovasines.

Penicillium chrysogenum secretes a low molecular weight, cationic and cysteine-rich protein (PAF). It has growth inhibitory activity against the model organism Aspergillus nidulans and numerous zoo- and phytopathogenic fungi but shows only minimal conditional antifungal activity against the producing organism itself. In this study we provide evidence for an additional function of PAF which is d...

The development and study of strains of Penicillium chrysogenum that give high yields of penicillin has been a major project at the University of Wisconsin during the past 12 years. Many thousands of cultures have been screened for their penicillin-producing ability in the Botany Department of the University. The methods used for the production and screening of mutants, the genealogy of the out...

Studies on the mechanism of glucose metabolism by penicillia are few. The fact that Snell (1949) and Kita (1951) found none of the phosphorylated esters of the Embden-Meyerhof scheme in PeniciUium chrysogenum, strain Q176, and that penicillia contain glucose oxidase (Birkinshaw and Raistrick, 1943) would indicate a priori that glucose is metabolized oxidatively by the mold. The following data i...