Background: Pemphigus is an autoimmune disease characterized with intra-epidermal cleavage. Objective: The aim of this study was to examine the clinical and epidemiologic features of pemphigus in Khouzestan province, southwest Iran. Patients and Methods: All new cases of pemphigus admitted in the department of dermatology, Sina Hospital, Ahwaz University from October 1990 to September 1999 were...

background: pemphigus vulgaris, a chronic mucocutaneous disease, is the most prevalent type of pemphigus which manifests with development of bullae and erosions on skin and mucosal membranes. objectives: to investigate the potential role of il-23 in pemphigus vulgaris. methods: in this study, 30 patients with pemphigus vulgaris and 30 healthy individuals were selected according to inclusion and...

BACKGROUND IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). CASE REPORT We report the case of an 60-year-old man with intraepidermal neutrophilic IgA pemphigus with IgA antibodies to Dsg1 and Dsg3. Histologic examinatio...

pemphigus is a rare autoimmune blistering disease with different phenotypes. the evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement. however, there is no gold standard to measure the disease activity in clinical trials. in this study we aimed to introduce the pemphigus vulgaris activity score (pvas) measurement and to assess the convergent validit...

BACKGROUND Despite the high incidence of pemphigus in the Jewish population, data on the epidemiology and etiology of the disease in Israel are sparse. OBJECTIVE This study was conducted to identify clinical and epidemiologic features of pemphigus patients in Israel, while searching for risk factors that induce or exacerbate the disease. METHODS Demographic and clinical information was reco...

Background: In addition to humoral immunity associated with anti-desmoglein antibodies, cellular immunity and mediators including cytokines are involved in the pathogenesis of pemphigus vulgaris. In this study we evaluated the level of IL-2, IFN-γ, TNF-α, IL-4, and IL-10 in the sera of patients with pemphigus vulgaris before and after treatment.Methods: A total number of 71 new patients with pe...

In pemphigus, autoantibodies form against desmoglein. Desmoglein forms the "glue" that attaches adjacent epidermal cells via attachment points called desmosomes. When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes "unglued", a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these bl...

Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis...