Membranes have been developed by coating a blend of chitosan (CS) and polyethylene glycol (PEG) of different molecular weights (4000, 10,000 and 20,000) on cotton fabric followed by freeze drying. The influence of PEG molecular weight on the physical characteristics of the membranes has been investigated. The scanning electron microscopy of the coated fabric reveals porous structure. The porosi...

The paper discusses general problems in using PEG for conjugation to high or low molecular weight molecules. Methods of binding PEG to different functional groups in macromolecules is reported together with their eventual limitations. Problems encountered in conjugation, such as the evaluation of the number of PEG chains bound, the localisation of the site of conjugation in polypeptides and the...

Excellent strength regenerated alginate composite fibers mixed with Poly (ethylene glycol) grafted cellulose nanocrystals (CNC-g-PEG) were prepared through a simple and scalable blending strategy. Firstly, high modulus (CNCs) fabricated based on waste cotton fabrics by the chemical treatment. (PEG) different molecular weight was onto CNC surface. The from CNC-g-PEG/sodium spinning dope wet spin...

We attempted to develop a novel method for the chemical modification of cytokines with synthetic polymers to increase in vivo therapeutic efficacy. A pH-reversible amino-protective reagent, dimethylmaleic anhydride (DMMAn), was used for polymer conjugation of tumor necrosis factor-alpha (TNF-alpha) with polyethylene glycol (PEG). The novel PEGylated TNF-alpha, PEG-TNF-alpha(+), which was pretre...

PEGylation is a successful approach to improve potency of a therapeutic protein. The improved therapeutic potency is mainly due to the steric shielding effect of PEG. However, the underlying mechanism of this effect on the protein is not well understood, especially on the protein interaction with its high molecular weight substrate or receptor. Here, experimental study and molecular dynamics si...

growing applications of phenylalanine dehydrogenase (phedh) enzyme in the medical and pharmaceutical industries encourages researchers to seek simple, fast and economical alternative purification methods. with goal of finding a new technique, the extraction and purification of recombinant bacillus badius phedh in polyethylene glycol 6000 (peg-6000) and ammonium sulfate aqueous two-phase systems...

Thermoresponsive polymer-based bilayer bending actuators rely on the dissimilar thermal expansion of polymers that form two layers. To maximize heat-induced change in curvature, shall be large one and small other material. Semicrystalline display a nonlinear across their melting transition, but as mechanical integrity is lost upon melting, they cannot readily used actuators. overcome this limit...

A novel method for the preparation of solvent-free poly(«-caprolactone) (PCL) microspheres from PCL/poly(ethylene glycol) (PEG) blends was developed and demonstrated. The particle size of the PCL spheres are in the range of 1 to 20 mm (mostly in the range 5–10 mm). The influences of the molecular weight of PCL, the molecular weight of PEG, the type of emulsifier, the concentration of plasticize...

Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and N-(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1) followed by ring-opening polymerization of amino acid N-carboxya...

A recombinant form of the high aYnity, natural inhibitor of tumour necrosis factor á (TNFá) is currently under development for the treatment of rheumatoid arthritis (RA). This molecule is referred to as recombinant-methionyl soluble TNF-type I receptor (r-metHu-sTNF-RI or sTNF-RI). Recombinant sTNF-RI is an Eschericia coli derived recombinant, truncated, monomeric form of the 4-domain soluble T...