The low aqueous solubility of celecoxib (CB) and thus its low bioavailability is a problem. Thus, it is suggested to improve the solubility using cosolvency and solid dispersions techniques. Pure CB has solubility of 6.26±0.23μg/ml in water but increased solubility of CB was observed with increasing concentration of cosolvents like PEG 400, ethanol and propylene glycol. Highest solubility (791....

Kesegaran sayur dapat dijaga dengan menyimpan dalam cold storage pada kondisi sejuk (5-10 °C). Polietilen glikol (PEG)-400 merupakan salah satu phase change material (PCM) yang memiliki rentang titik lebur 4 °C hingga 8 dan panas laten cukup besar yaitu 187 kJ/kg sehingga berpotensi untuk dikembangkan sebagai sistem . Pada penelitian ini diuji potensi PCM PEG-400 sayur. Massa divariasikan dari ...

A thermally fusible softwood lignin was directly isolated by a solvolysis of cedar wood chips with a mixture of polyethylene glycol 400 (PEG 400) and sulfuric acid. Its fusibility was found to be due to a PEG moiety introduced into the lignin by the solvolysis. The lignin was easily formed into fibers by melt-spinning at temperatures ranging from 145 to 172 o C without any modification. The lig...

Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl ...

Increased intestinal permeability in patients with Crohn's disease and their first degree relatives has been proposed as an aetiological factor. The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars (lactulose, l-rhamnose, and mannitol) was used to test the permeation in 47 patients with Crohn's disease of whom 18 had at least one first degree rela...

In this work, we have obtained nanoplasmonic silver structures deposited on the glass substrates by combining sol-gel technology and direct silver ion reduction on the film surfaces. The key point of the work was the usage of polyethylene glycol 400 (PEG 400) both as the pore former and reducing agent for silver ions. We have investigated the influence of PEG 400 amount on the formation of silv...

Aim: The present study was intended to develop some novel imidazole derivatives via multi-component reaction catalysed by Ceric Ammonium Nitrate (CAN) in polyethylene glycol-400 (PEG-400) and its HMG-CoA reductase inhibitory activity for benefit in atherosclerosis. Methods: The one-pot synthesis has been achieved by taking benzyl, benzaldehyde, 3-amino-1, 2, 4triazole-5carboxylic acid (0.01 mol...