We describe the behavior of hemostatic variables in children with portal vein thrombosis (PVT) and in a control pediatric population. Hereditary protein C (PC) or protein S (PS) deficiency was not a etiologic factor for PVT in children. Minor signs of consumption of coagulation factors II, V, fibrinogen and hyperfibrinolysis were detected. One child had lupus anticoagulant (LA).

Optimal treatment for lupus nephritis in adolescents is still a great challenge. Systemic lupus erythematosus (SLE) is a chronic disease characterized by frequent disease flares for which effective and safe maintenance therapy is required (Chan et al., 2005; Lai et al., 2005). Since diffuse proliferative lupus nephritis (DPLN) is a major concern regarding treatment of young patients with SLE, t...

Hypertension is an important manifestation of systemic lupus erythematosus (SLE) but reports of prevalence vary between 20-70% in published reports of adult and pediatric patients. For both children and adults with SLE, the clinical diagnosis and management of hypertension has traditionally been based on guidelines developed for the general population. In clinical trials, the criteria used for ...

Background: Since viral infections activate type I interferon (IFN) pathways and cause subsequent release of IFN-dependent proinflammatory chemokines/cytokines, the innate immune system plays an important role in the pathogenesis of lupus nephritis (LN) as well as systemic lupus erythematosus. With respect to this issue, mesangial chemokine/cytokine expressions via innate immunity reportedly pl...

Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease with higher incidence and increased disease severity, including increased medication requirements and morbidity, in people not uniquely of European descent. Few studies explore the differences between ethnic groups at presentation and early in the disease process, and no studies exist to our knowledge specifically evaluating th...

Methods Three main lupus centers from Europe were included in this study. One of these centers was mainly a pediatric nephrology center from UK whereas one was a pediatric rheumatology center from Italy and the last one was a joint one from Turkey. Features present at onset in childhood-onset SLE (cSLE) patients, diagnosed and followed by these three departments between January 2000 to December...

Methods Retrospective study of patients followed in Necker-Enfants Malades Hospital (Pediatric Rheumatology, Pediatric Dermatology) from january 2002 to march 2014, with overlap myositis defined by the association of inflammatory myositis and clinic features and/or biological signs of other connective tissue diseases (clinical features among polyarthritis, Raynaud syndrome, sclerodactyly, morph...

BACKGROUND Vitamin D deficiency has been associated with systemic lupus erythematosus (SLE), but there is no consensus on the role of serum vitamin D in evaluating or predicting disease activity. This study aimed to demonstrate the direct correlation between vitamin D level and pediatric-onset SLE disease activity by a retrospective cohort study design. PATIENTS AND METHODS Thirty-five patien...

OBJECTIVE To determine the serum levels of interferon alpha in childhood-onset systemic lupus erythematosus patients, their first-degree relatives and healthy controls and to evaluate the associations between serum interferon alpha and disease activity, laboratory findings and treatment features. METHODS We screened consecutive childhood-onset systemic lupus erythematosus patients in a longit...

OBJECTIVE To assess CD154 expression in patients with pediatric systemic lupus erythematosus (SLE) and to explore a transcriptional mechanism that may explain dysregulated expression of CD154. METHODS Cell surface CD154 expression (pre- and postactivation) in peripheral blood CD4 T cells from 29 children with lupus and 29 controls matched for age, sex, and ethnicity was examined by flow cytom...