Testing hypotheses related to the effect of gravitational orientation on neural control mechanisms is difficult for most locomotor tasks, like walking, because body orientation with respect to gravity affects both sensorimotor control and task mechanics. To examine the mechanical effect of body orientation independently from changes in workload and posture, Brown et al. (J. Biomech. 29 p. 1349,...

The objectives of this study were twofold. The first was to develop a forward dynamic model of cycling and an optimization framework to simulate pedaling during submaximal steady-state cycling conditions. The second was to use the model and framework to identify the kinetic, kinematic, and muscle timing quantities that should be included in a performance criterion to reproduce natural pedaling ...

Many researchers have used cycling exercise to evaluate muscle metabolism. Inherent in such studies is an assumption that changes in whole-body respiration are due solely to respiration at the working muscle. Some researchers, however, have speculated that the metabolic cost of torso stabilization may contribute to the metabolic cost of cycling. Therefore, our primary purpose was to determine w...

Nitrogen, one of the most abundant elements in nature, forms the highly stable N2 molecule in its elemental state. In contrast, polynitrogen compounds comprising only nitrogen atoms are rare, and no molecular crystal made of these compounds has been prepared. Here, we predict the existence of such a molecular solid, consisting of N8 molecules, that is metastable even at ambient pressure. In the...

Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. To evaluate long-term safety of N8-GP, 26- and 52-week tox...

objectives in this study, we aimed to investigate the changes in brain lipidomics following prolonged and intermittent ischemic preconditioning. materials and methods two groups underwent bilateral common carotid artery occlusion either intermittently (for 3 continuous periods within a timeframe of 20 minutes, releasing 3 consecutive times, yielding a total of 9 minutes (intermittent bilateral ...

Purpose: Doing plyometric training with and without the vessel occlusion is an effective practice for rapid increase of muscles strength their hypertrophy. We evaluated the effects of plyometric training with and without the vessel occlusion on electromyographic parameters. Methods: In this quasi-experimental study, 22 females were selected through convenience sampling method. They were random...

The biologic fate of the [(3)H]PEG-moiety incorporated into N8-GP was evaluated based on single i.v. bolus doses to rats. Furthermore, the 40kDa [(3)H]PEG-moiety was given separately to rats by single i.v. bolus doses, to investigate if the pharmacokinetics were dose-dependent. For both compounds, plasma pharmacokinetics, distribution and excretion pathways were investigated, based on total rad...

BARRATT, P. R., T. KORFF, S. J. ELMER, and J. C. MARTIN. Effect of Crank Length on Joint-Specific Power during Maximal Cycling.Med. Sci. Sports Exerc., Vol. 43, No. 9, pp. 1689–1697, 2011. Previous investigators have suggested that crank length has little effect on overall short-term maximal cycling power once the effects of pedal speed and pedaling rate are accounted for. Although overall maxi...

INTRODUCTION The cardiorespiratory and muscular strength benefits of functional electrical stimulation (FES) pedaling for spinal cord injury (SCI) subjects are limited because the endurance of electrically stimulated muscle is low. METHODS We tested new electrical stimulation timing patterns (Stim3, designed using a forward dynamic simulation to minimize the muscle stress-time integral) to de...