Coumarin-4-acetic acids have been synthesized from various phenols and citric acid under Pechmann cyclisation conditions. All the compounds have been evaluated for antiinflammatory and analgesic activity in acute models. Compounds have also been evaluated for their ulcerogenic potential. Using the computer program, prediction of activity spectra for substances, prediction results and their Phar...

Die Ökologie warnt vor der Erderwärmung, die Soziologie sozialer Ungleichheit: beides bedroht das Überleben kommenden Generationen. Alexander von Pechmann behandelt aus rechtsphilosophischer Perspektive Frage, welche künftigen Formen des Eigentums diesen globalen Herausforderungen gewachsen sind. Er kommt zu dem Ergebnis, dass weder kapitalistische Privateigentumsrecht noch nationale Souveränit...

paid mass-media advertising to communicate with the U.S. public. The U.S. Congress has allocated $1.2 billion—$200 million per year for 5 years—to fund an advertising campaign to keep youths from using illicit drugs (Fairclough, 1999). The U.S. Census Bureau has, for the first time, used advertising to increase mail-in response rates to the dicennial census; its advertising budget was roughly $...

nano sulfated titania was tested as solid acid heterogeneous catalyst for the synthesis of 4-(trifluoromethyl) coumarin and coumarin derivatives under solvent-free condition. factorial design evidenced a positive effect of reaction temperature, amount of catalyst, and solvents.  this nano-sized sulfated titania has been prepared by a sol-gel hydrothermal process. the prepared sulfated titania s...

Inga U. Schapitz,1* Bardo Behrend,1* Yvonne Pechmann,1 Corinna Lappe-Siefke,1 Silas J. Kneussel,1 Karen E. Wallace,3 A. Vanessa Stempel,5 Fritz Buck,2 Seth G. N. Grant,4 Michaela Schweizer,1 Dietmar Schmitz,5 Jürgen R. Schwarz,1 Erika L. F. Holzbaur,3 and Matthias Kneussel1 1Center for Molecular Neurobiology (ZMNH), University of Hamburg Medical School, D-20251 Hamburg, Germany, 2Institute of C...

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Abstract Many coumarin derivatives have good biological activity and application value in fluorescent probes. Therefore, synthetic routes to also attracted the attention of many research groups. In this work, based on Pechmann synthesis method, influence various Lewis acids reaction was discussed, optimal conditions 7-hydroxy-4-substituted coumarins were explored. Based experimental results, a ...

New modified acidic catalysts were prepared from the treatment of silica, titania and silica prepared from hydrolyzed tetraethyl orthosilicate (TEOS) with sulfuric and phosphoric acid. The sulfated and phosphated silica synthesized from TEOS were calcined at 450 and 650 ◦C. These catalysts were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), transmissio...

Referring expressions (such as the red chair facing right) often show evidence of preferences (Pechmann, 1989; Belke & Meyer, 2002), with some attributes (e.g. colour) being more frequent and more often included when they are not required, leading to overspecified references. This observation underlies many computational models of Referring Expression Generation, especially those influenced by ...