BACKGROUND Diagnosis of pulmonary embolism (PE) is difficult in patients with chronic obstructive pulmonary disease (COPD) and exacerbation. OBJECTIVE To evaluate PE in patients with COPD and exacerbation of unknown origin and explore factors associated with PE. DESIGN Prospective cohort study. SETTING University-affiliated hospital in France. PATIENTS 211 consecutive patients, all curr...

Blood flow patterns in conduit arteries characterized by high levels of retrograde shear stress can be detrimental for vascular health. In this study we examined whether retrograde shear rate and endothelial function are related in healthy and formerly preeclamptic (PE) women and whether this relationship is altered by exercise training. Formerly PE women (32 ± 4 yr, n = 20) and controls (32 ± ...

The effects of eritadenine, a constituent of the Lentinus edodes mushroom, and ethanolamine, the base constituent of phosphatidylethanolamine (PE), on fatty acid desaturase activities and lipid profiles were investigated comparatively in rats. Rats were fed a control diet or a diet supplemented with either eritadenine (0.05 g/kg) or ethanolamine (8 g/kg) for 14 d. Eritadenine and ethanolamine h...

The identification of normotensive patients with acute pulmonary embolism (PE) at high risk of adverse PE-related clinical events (i.e. intermediate-risk group) is a major challenge. We combined individual patient data from six studies involving 2874 normotensive patients with PE. We developed a prognostic model for intermediate-risk PE based on the clinical presentation and the assessment of r...

OBJECTIVE To assess whether glycemic control, soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) were associated with the development of preeclampsia (PE) or gestational hypertension (GHTN) in women with preexisting diabetes. METHODS Maternal circulating angiogenic factors (sFlt1 and PlGF) measured on automated platform were studied at four time points during pregna...

INTRODUCTION The severity of acute pulmonary embolism can be assessed with computed tomography (CT) using clot burden estimation. We compared the existing CT obstruction scores with an in-house developed central clot score for the prediction of 30-day pulmonary embolism (PE)-related mortality. MATERIALS AND METHODS In 125 consecutive patients [47 men, 78 women; mean age +/- standard deviation...

Obesity increases pre-eclampsia (PE) risk. Adipose tissue inflammation may contribute to the clinical syndrome of PE. We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from healthy (n=13) and PE (n=13) mothers. Basal and lipopolysaccharide (LPS) stimulated ad...

BACKGROUND Pericardial effusion (PE) is one of the most frequent complications from catheter ablation of atrial fibrillation (AF). We assessed the prevalence and predictive factors of PE that require invasive treatment as an early complication of AF ablation. METHODS The Japanese Heart Rhythm Society requested electrophysiology centers to register the relevant data of patients who underwent A...

Non-alcoholic fatty liver disease (NAFLD) is clinically characterized as uncontrolled fat accumulation in the liver resulting in inflammatory responses, insulin resistance, elevated liver enzymes, and ultimately liver failure. Currently, there are no clinical lipid markers detectable by blood test to ascertain the manifestation of improper fat regulation in the liver. The cell membranes of hepa...