نتایج جستجو برای: pdgfr β

تعداد نتایج: 178428  

2013
Yi Guo Jiangyan Yin Lang Zha Ziwei Wang

AIM OF THE STUDY Platelet-derived growth factor B (PDGF-B), a vital growth factor which can induce angiogenesis and epithelial-mesenchymal transition (EMT), is important in the metastasis of many tumors. However, the roles of PDGF-B in gastric carcinoma are largely unknown. We investigated the correlation between PDGF-B, PDGFR-β and E-cadherin expression with the clinical features of gastric ca...

2015
Qiulian Zhou Lei Wei Chongjun Zhong Siyi Fu Yihua Bei Radu-Ionuț Huică Fei Wang Junjie Xiao

Telocytes (TCs) are a distinct type of interstitial cells, which are featured with a small cellular body and long and thin elongations called telopodes (Tps). TCs have been widely identified in lots of tissues and organs including heart. Double staining for CD34/PDGFR-β (Platelet-derived growth factor receptor β) or CD34/Vimentin is considered to be critical for TC phenotyping. It has recently ...

2013
Bjoern Neubauer Katharina Machura Verena Rupp Michelle D Tallquist Christer Betsholtz Maria Luisa S Sequeira-Lopez R Ariel Gomez Charlotte Wagner

Apart from their endocrine functions renin-expressing cells play an important functional role as mural cells of the developing preglomerular arteriolar vessel tree in the kidney. The recruitment of renin-expressing cells from the mesenchyme to the vessel wall is not well understood. Assuming that it may follow more general lines of pericyte recruitment to endothelial tubes we have now investiga...

2016
Artur Mezheyeuski Maja Bradic Lindh Tormod Kyrre Guren Anca Dragomir Per Pfeiffer Elin H. Kure Tone Ikdahl Eva Skovlund Sara Corvigno Carina Strell Kristian Pietras Fredrik Ponten Jan Mulder Camilla Qvortrup Anna Portyanko Kjell Magne Tveit Bengt Glimelius Halfdan Sorbye Arne Östman

Perivascular cells (PC) were recently implied as regulators of metastasis and immune cell activity. Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal canc...

Journal: :JCI insight 2017
Mary C Drinane Usman Yaqoob Haibin Yu Fanghong Luo Thomas Greuter Juan P Arab Enis Kostallari Vikas K Verma Jessica Maiers Thiago Milech De Assuncao Michael Simons Debabrata Mukhopadhyay Tatiana Kisseleva David A Brenner Raul Urrutia Gwen Lomberk Yandong Gao Giovanni Ligresti Daniel J Tschumperlin Alexander Revzin Sheng Cao Vijay H Shah

The scaffold protein synectin plays a critical role in the trafficking and regulation of membrane receptor pathways. As platelet-derived growth factor receptor (PDGFR) is essential for hepatic stellate cell (HSC) activation and liver fibrosis, we sought to determine the role of synectin on the PDGFR pathway and development of liver fibrosis. Mice with deletion of synectin from HSC were found to...

2017
Nina A. Maihöfer Said Suleiman Daniela Dreymüller Paul W. Manley Rolf Rossaint Stefan Uhlig Christian Martin Annette D. Rieg

BACKGROUND Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-derived growth factor (PDGF)-receptor (PDGFR), acts antiproliferative and relaxes pulmonary arteries. However so far, the relaxant effects of imatinib on pulmonary veins (PVs) and ...

2014
Courtney L. Donica Yan Cui Shanping Shi Howard B. Gutstein

BACKGROUND Chronic, intractable pain is a problem of pandemic proportions. Pain caused by nerve injuries (neuropathic pain) is extremely difficult to treat. For centuries, opiates such as morphine have been the first-line treatment for severe chronic pain. However, opiates are often ineffective against neuropathic pain, leaving few options for suffering patients. We previously demonstrated that...

Journal: :Journal of Enzyme Inhibition and Medicinal Chemistry 2021

A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesised under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The compounds 4b, 4j, 4k, 4e exhibited the most potent activity IC50 values (0.002 − 0.004 µM) comparing to Staurosporine IC50; 0.005 μM. latter derivatives a p...

2012
Inga Nazarenko Sanna-Maria Hede Xiaobing He Anna Hedrén James Thompson Mikael S. Lindström Monica Nistér

The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in normal embryonic development, cellular differentiation, and response to tissue damage. Not surprisingly, as it is a multi-faceted regulatory system, numerous pathological conditions are associated with aberrant activity of the PDGFs and their receptors. As we and others have shown, human gliomas, especiall...

2013
Michela Garofalo Young-Jun Jeon Gerard J. Nuovo Justin Middleton Paola Secchiero Pooja Joshi Hansjuerg Alder Natalya Nazaryan Gianpiero Di Leva Giulia Romano Melissa Crawford Patrick Nana-Sinkam Carlo M. Croce

Lung cancer is the leading cause of cancer mortality in the world today. Although some advances in lung cancer therapy have been made, patient survival is still poor. MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignancy. The miR-34 family consists of tumor-suppressive miRNAs, and its reduced expression has been reported in various cancers, including non-small ce...

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