CD44 and prostate stem cell antigen (PSCA) have been investigated as two biomarkers for various cancers. However, either CD44 or PSCA expression alone has limited clinical value. In the present study, the expression of CD44 and PSCA in human pancreatic ductal adenocarcinoma (PDAC) and their values in prognosis were investigated by immunohistochemistry (IHC) and Kaplan-Meier method. The results ...

Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases, and occurs in prokaryotes and eukaryotes. OGFOD1 catalyzes trans-3 prolyl hydroxylation at Pro62 of the small ribosomal subunit protein uS12 (RPS23) and is conserved from yeasts to humans. We describe crystal structures of the human uS12 prolyl 3-hydroxylase (OGFOD1) an...

Viral dsRNA can be found at the site of inflammation in RA patients, and intra-articular injection of dsRNA induces arthritis by activating type I IFN signaling in mice. Further, DCs, a major source of IFN-α, can be found in the synovium of RA patients. We therefore determined the occurrence of DCs in dsRNA-induced arthritis and their ability to induce arthritis. Here, we show, by immunohistoch...

Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privileged CNS upon infection with neurotropic viruses has not been completely defined. Notably, DC roles in regulating innate CD11b(+)Ly-6C(hi) monocyte functions during neuroinflammation have not yet ...

An important challenge to occupational health services in Japan is the necessary shift from regulation-based occupational health program to health risk-based program. The Occupational Safety and Health Management System (OSHMS) is an effective tool for introducing risk-based activities. To date, the Five Management system has been used to manage occupational health activities. This classificati...

Clinical laboratories must adhere to Good Laboratory Practices (GLP) to ensure the quality, integrity, and reliability of patient results. GLP principles include organization and personnel, a quality assurance program, facilities, equipments, reagents and materials, test systems, standard operating procedures, result reporting, and archiving of records and reports (Wikipedia,2010). This chapter...