Morphogenesis and physiology of tissues and organs requires planar cell polarity (PCP) systems that orient and coordinate cells and their behaviors, but the relationship between PCP systems has been controversial. We have characterized how the Frizzled and Dachsous-Fat PCP systems are connected through the Spiny-legs isoform of the Prickle-Spiny-legs locus. Two different components of the Dachs...

Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations have been associated with failure of sulfa prophylaxis; their effect on the outcome of patients with P. jirovecii pneumonia (PCP) remains controversial. P. jirovecii DHPS polymorphisms and genotypes were identified in 112 cases of PCP in 110 HIV-infected patients by using PCR single-strand conformation polymorphism. Of the 110 pat...

Phencyclidine (PCP) was analyzed for its ability to inactivate human cytochrome p450 (p450) 2B6. PCP inactivated the 7-ethoxy-4-(trifluoromethyl)coumarin O-deethylation activity of p450 2B6 in a concentration-, time-, and NADPH-dependent manner and exhibited pseudo-first order kinetics. The K(I) was 10 microM, k(inact) was 0.01 min(-1), which corresponds to a t(1/2) of 31 min. The partition rat...

Anaerobic granules degrading pentachlorophenol (PCP) with specific PCP removal activity up to 14.6 mg/g of volatile suspended solids per day were developed in a laboratory-scale anaerobic upflow sludge blanket reactor at 28 degrees C, by using a mixture of acetate, propionate, butyrate, and methanol as the carbon source. The reactor was able to treat synthetic wastewater containing 40 to 60 mg ...

We evaluated the use of straw compost and remediated soil as inocula for bioremediation of chlorophenol-contaminated soil. The in situ biotransformation of pentachlorophenol (PCP) and mineralization of radiolabeled [U-(sup14)C]PCP by straw compost and remediated soil were studied under field-simulating conditions before and after 3 months of adaptation with PCP in a percolator. After PCP adapta...

several authors have indicated that pcp is a toxic chemical and recalcitrant to biodegradation. aops is one of the moste effective process for degradation of persistant compound.since the mineralization of recalcitrant compound by aops (advanced oxidation processes) often requires long reaction time and strong doses of oxidant, the combination of this process with biological one, considered as ...

We introduce a version of Post Correspondence Problem (PCP, in short) generalized to words over partially commutative alphabets. Several observations are presented about the algorithmic status of the introduced problem. In particular solvability is shown for the partially commutative PCP for two special cases: the binary case of PCP (denoted by PCP(2) ), and the case with one periodic morphism....

This paper presents a performance comparison of three multiprocessor real-time locking protocols: the multiprocessor priority ceiling protocol (M-PCP), the distributed priority ceiling protocol (D-PCP), and the flexible multiprocessor locking protocol (FMLP). In the FMLP, blocking is implemented via either suspending or spinning, while in the M-PCP and D-PCP, all blocking is by suspending. The ...

We investigated the sorption kinetics of pentachlorophenol (PCP) on soil at a pH of 4.1 using batch techniques. A multiple spiking methodology was employed to circumvent the solubility limitation of PCP. The ratio of sorbed PCP to solution-phase PCP (S/C) after 2-4 days of equilibration was concentration dependent. It decreased from 90 to 60 L/kg with a 4-fold increase in the total PCP concentr...

BACKGROUND The psychotomimetic phencyclidine (PCP) produces behavioral symptoms similar to those observed in schizophrenia, accompanied by increased motor activity. The dopamine and adenosine 3',5'-cyclic monophosphate-regulated phosphoprotein of 32kDa (DARPP-32) is enriched in the medium spiny neurons (MSNs) of the striatum and has been implicated in the actions of PCP. We examined the effects...