Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance and hyperandrogenism. The interaction of these factors might result in increased risks of miscarriage and pregnancy complications such as gestational diabetes mellitus (GDM). To examine the pregnancy risks in women with PCOS, we compared obstetrical outcomes between patients with and without PCOS...

Novel insights into the pathophysiology of PCOS: the role of environmental toxins. Polycystic ovary syndrome PCOS is a common endocrine disorder which. Pathogenesis of this syndrome still remains elusive. The definition, pathogenesis, and etiology of PCOS will be reviewed. 2012pcosdocsPCOSFinalStatement.pdf Accessed on April 29.The majority of patients with PCOS are insulin resistant and PCOS i...

Oxidative stress seems to be present in patients with polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the correlation between characteristics of PCOS and serum concentrations of afamin, a novel binding protein for the antioxidant vitamin E. A total of 85 patients with PCOS and 76 control subjects were investigated in a pilot cross-sectional study design between 2009 and ...

Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an ...

Background: Hyperandrogenism (HA), inflammation, and oxidative damage play key roles in the pathophysiology of polycystic ovary syndrome (PCOS). Whether vitamin D adjuvant therapy improves hormonal, PCOS patients has aroused widespread interest, but results are controversial. To evaluate effect supplementation on stress, inflammatory parameters with PCOS.

STUDY QUESTION Is there an association between polycystic ovary syndrome (PCOS) and the sex hormone-binding globulin (SHBG) rs1799941, rs6257, rs6259 and rs727428 variants in a large series of Mediterranean women? SUMMARY ANSWER The rs727428 and rs6259 variants are associated with PCOS in Mediterranean women. WHAT IS KNOWN ALREADY The level of SHBG, the primary plasma transport protein for ...

The release and regulation of betatrophin in women with polycystic ovary syndrome (PCOS) haven’t been well known. The study was to investigate circulating betatrophin levels in women with PCOS and the correlations with insulin resistance and biochemical parameters in two cohorts. In cohort 1, 90 women with PCOS and 85 age-matched healthy women were recruited in a cross-sectional study. Serum co...

OBJECTIVE ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS). We aimed to determine the serum versican and ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) levels in PC...

BACKGROUND Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. A higher prevalence of psychiatric comorbidities, including depressive disorder, anxiety disorder, and bipolar disorder has been proved in patients with PCOS. However, a clear temporal causal relationship between PCOS and psychiatric disorders has not been well established....

BACKGROUND The link between AIT and PCOS has been reported on several studies, but it's true pathogenesis is far from being elucidated. In an attempt to provide evidence of the relationship between PCOS and AIT, relevant literature of AIT markers in women with PCOS was reviewed and analyzed. METHODS PubMed, Embase, Medline, Web of Knowledge and the Cochrane trial register were searched with E...