The utilization of cutting planes is a key technique in Integer Linear Programming (ILP). However, cutting planes have seldom been applied in Pseudo-Boolean Optimization (PBO) algorithms derived from the Davis-Logemann-Loveland (DLL) procedure for Propositional Satisfiability (SAT). This paper proposes the utilization of cutting planes in a DLL-style PBO algorithm, which incorporates the most e...

We fabricated a series of glasses with the composition 94.7GeO2-5Al2O3-0.3Bi2O3PbO =0–24 mol. % . Characteristic absorption bands of bismuth centered at 500, 700, 800, and 1000 nm were observed. Adding PbO was found to decrease the strength of bismuth absorption. The addition of 3%–4% PbO resulted in a 50% increase in lifetime, a 20-fold increase in quantum efficiency, and a 28-fold increase in...

Combinations of drugs with distinct and complementary mechanisms of action may offer improved efficacy in the treatment of chronic obstructive pulmonary disease (COPD). In two 12-week, double-blind, parallel-group studies, patients with COPD were randomized 1:1:1 to once-daily umeclidinium (UMEC; 62.5 μg and 125 μg) or placebo (PBO), added to twice-daily fluticasone propionate/salmeterol (FP/SA...

The novel polymer poly[p-(2,5-dihydroxy)-phenylenebenzobisoxazole] (PBOH) fiber was synthesized in the presence of 2,5-dihydroxyterephthalicacid (DHTA) and 4,6-diamino-1,3-benzenediol in poly(phosphoric acid) (PPA) using typical polycondensation conditions. The crystalline solutions of liquid PBOH in PPA were spun into fibers using dry-jet wet spinning. Furthermore, the thermostability and mech...

OBJECTIVE In the Treatment for Adolescents with Depression Study (TADS), fluoxetine (FLX) and the combination of fluoxetine with cognitive-behavioral therapy (COMB) had superior improvement trajectories compared to pill placebo (PBO), whereas cognitive-behavioral therapy (CBT) was not significantly different from PBO. Because attention-deficit/hyperactivity disorder (ADHD) and major depressive ...

Fiber Reinforcement Polymer(FRP) has been widely accepted as an innovative material for renovation and strengthening of existing infrastructures. Among the FRP materials, the Poly-p-phenylene benzobisoxazole (PBO) fiber sheets attracted great attention in recent years because of the high strength, high Young modulus and high energy absorption capability. In this study, a PBO Prestressing Upgrad...

1300 ACHIEVING A COMPOSITE ENDPOINT OF A1C, BODY WEIGHT, AND SYSTOLIC BLOOD PRESSURE REDUCTION WITH CANAGLIFLOZIN IN PATIENTS WITH TYPE 2 DIABETES Katherine Merton, PhD, MBA1, Michael Davies, PhD1, Ujjwala Vijapurkar, PhD2, Doreen Inman, PharmD, MBA, BCPS, CDE1, Gary Meininger, MD2 1. Janssen Scientific Affairs, LLC, 2. Janssen Research & Development, LLC Objective: Achieving glycemic control, ...

Bayesian optimization (BO) has emerged during the last few years as an effective approach to optimizing black-box functions where direct queries of the objective are expensive. In this paper we consider the case where direct access to the function is not possible, but information about user preferences is. Such scenarios arise in problems where human preferences are modeled, such as A/B tests o...

Muscle contraction is normally mediated by the release of neurotransmitters from motor neurons. Here we demonstrate that protons can act as a direct transmitter from intestinal cells to stimulate muscle contraction. During the C. elegans defecation motor program the posterior body muscles contract even in the absence of neuronal inputs or vesicular neurotransmission. In this study, we demonstra...

Synergistic effects of verbutin, a member of aryl alkynyl derivatives, to three commonly used acaricides were evaluated with the modified Food and Agricultural Organization Larval Packet Test (FAO-LPT) against both susceptible and resistant strains of the southern cattle tick, Rhipicephalus (Boophilus) microplus (Canestrini) (Acari: Ixodidae). These tick strains demonstrated various levels of r...