Antibiotic tolerance, the capacity of genetically susceptible bacteria to survive the lethal effects of antibiotic treatment, plays a critical and underappreciated role in the disease burden of bacterial infections. Here, we take a pathogen-by-pathogen approach to illustrate the clinical significance of antibiotic tolerance and discuss how the physiology of specific pathogens in their infection...

key dissimilarities between thermophilic and mesophilic anaerobic digestion of waste activated sludge (was) were experimentally studied in this research. typical was with total solids (ts) concentrations of 30 and 60 g/l were digested anaerobically in a batch digester at mesophilic and thermophilic temperatures. solids reduction, total cod changes, the production of different volatile fatty ...

in recent years due to changes in lifestyle and eating behavior of the human populations, disease caused by contaminated food has increased significantly. listeria monocytogenes, escherichia coli o157:h7 and salmonella enteric are three of the most important food borne bacterial pathogens and can lead to food borne diseases. also today wide spread of resistance to antibiotics among bacteria occ...

an isolate of fusarium moniliforme, a pathogen of winter wild oat (avena ludoviciana), was obtained from tehran province, iran, in 1994. a host range test performed on wheat, barley, maize, rye, millet, crested wheatgrass, faba bean, red bean, green bean, sunflower, soybean, oilseed rape, cotton, safflower, cucumber, water melon, berseem clover, and sainfoin, resulted in no symptom induction by...

The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus a...

Plant immune responses are triggered by pattern recognition receptors that detect conserved pathogen-associated molecular patterns (PAMPs) or by resistance (R) proteins recognizing isolate-specific pathogen effectors. We show that in barley, intracellular mildew A (MLA) R proteins function in the nucleus to confer resistance against the powdery mildew fungus. Recognition of the fungal avirulenc...

Exposure to low doses of pathogens that do not result in the host becoming infectious may 'prime' the immune response and increase protection to subsequent challenge. There is increasing evidence that such immune priming is a widespread and important feature of invertebrate host-pathogen interactions. Immune priming clearly has implications for individual hosts but will also have population-lev...

Interferon inducible protein kinase PKR is a component of innate immunity and mediates antiviral actions by recognizing pathogen associated molecular patterns (PAMPs). A well-known activator of PKR is long dsRNA, which can be produced during viral replication. Our recent results indicate that PKR can also be activated by short stem-loop RNA in a 5'-triphosphate-dependent fashion. A 5'-triphosph...