BACKGROUND We documented previously the entity of trichloroethylene (TCE) hypersensitivity syndrome (THS) in occupational workers. OBJECTIVES To identify the culprit causative compound, determine the type of hypersensitivity of THS, and establish a screening test for subjects at risk of THS. METHODS TCE and its main metabolites chloral hydrate (CH), trichloroethanol (TCOH) and trichloroacet...

Introduction: Allergic and irritant compounds are frequent in nature, and the environmental allergic factors which can induce or exacerbate eczema are different and often unknown in different areas. The aim of this study was to determine the frequency of contact dermatitis in patients with chronic dermatitis referring to dermatology clinics in kerman. Methods: In this descriptive study, standar...

Atopic eczema/dermatitis syndrome (AEDS) is a chronic, intermittent, inflammatory, genetically predisposed skin disease characterized by severe pruritus and xerosis. AEDS is a common disorder in children with an increasing prevalence. A number of environmental factors have been implicated in the pathogenesis of AEDS. Atopy patch test (APT) is a patch test using type Iota allergens known to elic...

BACKGROUND Patch testing has previously been shown to influence the quality of life, although a very few studies have shown if this is dependent on the result of the patch tests. OBJECTIVE To assess the impact of patch testing on the quality of life (QOL) in patients with hand eczema (HE). METHODS A total of 50 patients diagnosed of hand eczema at the time of patch testing, aged 16 years an...

BACKGROUND In the latest decades, epidemiological studies on allergic disorders in children, including atopic dermatitis, rhinitis and asthma, demonstrated a continuous increase in prevalence. However, such studies are usually performed by questionnaires and, sometimes, by skin prick test or in vitro IgE tests, while the portion of allergy sustained by the cell-mediated mechanism is neglected, ...

BACKGROUND Differences exist between the rates of patients with positive patch test reactions in different centres. OBJECTIVES To explore the varying relationship between the percentage of patients with one or more positive reactions (rate of patients with positive reactions) and the proportion of the population tested annually (intensity of testing) by UK centres contributing to a shared dat...