Ultrasonic manipulation has emerged as a simple and powerful tool for trapping, aggregation, and separation of cells. During the last decade, an increasing amount of applications in the microscale format has been demonstrated, of which the most important is acoustophoresis (continuous acoustic cell or particle separation). Traditionally, the technology has proven to be suitable for treatment of...

A device for acoustic particle manipulation in the 40 MHz range for continuous-flow operation in a 50 μm wide PDMS channel has been evaluated. Unidirectional interdigital transducers on a Y-cut Z-propagation lithium nixobate wafer were used to excite a surface acoustic wave that generated an acoustic standing wave inside the microfluidic channel. It was shown that particle alignment nodes with ...

In this paper, a fine particle manipulation system using a piezoresistive microcantilever, which is normally utilized in Atomic Force Microscopy, as the manipulator and force sensor, and a top-view Optical Microscope (OM) as the vision sensor is proposed. Modeling and control of the interaction forces among the manipulator, particle and surface have been realized for moving particles with sizes...

We demonstrate controlled manipulation of large quantities of microparticles on a surface using inertial forces. Motion is induced by applying a periodic parabolic wave form to a shear-polarized piezoelectric plate coupled to a substrate on which the particles reside. Particles move in steps of 10 to 50 nm per cycle, and the particle motion is mass selective. Particle velocity is varied by chan...

Ultrasonic particle manipulation technique is a non-contact label-free method for manipulating micro- and nano-scale particles using ultrasound, which has obvious advantages over traditional optical, magnetic, electrical micro-manipulation techniques; it gained extensive attention in micro-nano recent years. This paper introduces the basic principles methods of ultrasonic techniques, provides d...