نتایج جستجو برای: parthenolide
تعداد نتایج: 420 فیلتر نتایج به سال:
Abstract Funding Acknowledgements Type of funding sources: None. Background The cardiac sodium channel Nav1.5 is transported to the membrane by microtubule network. Alterations in dynamics are known impact on ion trafficking. Pathophysiological conditions such as heart failure and Duchenne muscular dystrophy (DMD) associated with an increase detyrosination well a decreased current (INa) pro-arr...
The molecular mechanisms underlying the acquisition of resistance to the antiestrogen Faslodex are poorly understood, although enhanced expression and activity of nuclear factor KB (NFKB) have been implicated as a critical element of this phenotype. The purpose of this study was to elucidate the mechanism by which NFKB up-regulation contributes to Faslodex resistance and to determine whether ph...
Aims: To investigate the effect of parthenolide on nucleolin in controlling expression miR-375 that induces apoptosis and cell cycle arrest prostate cancer.
 Study Design: This study is an experimental study.
 Methodology: The cytotoxicity was tested by MTT assay for 48 h. Microscopic techniques were used to identify morphological changes line. apoptotic regulatory genes analyzed Real...
BACKGROUND Parthenolide (PTL) is a sesquiterpene lactone which can induce apoptosis in cancer cells and eradicate cancer stem cells such as leukemia stem cells, prostate tumor-initiating cells and so on. However, the mechanism remains largely unclear. METHODS Lung cancer cells were treated with parthenolide and the cell lysates were prepared to detect the given proteins by Western Blot analys...
The purpose of this study was to compare and analyse active components in feverfew and chamomile using High Performance Thin Layer Chromatography as the analytical method. Both plants belong to the same Asteraceae family and feverfew is sometimes mistaken for German chamomile due to similar flowers. Feverfew leaves have been traditionally used in the treatment of migraine, with Parthenolide reg...
Detyrosination of α-tubulin seems to be conserved in all eukaryotes. However, its biological function in plants has remained obscure. A conserved C-terminal tyrosine is removed by a still unidentified tubulin-tyrosine carboxypeptidase (TTC) and can be religated by a tubulin-tyrosine ligase (TTL). To obtain insight into the still elusive biological function of this detyrosination-tyrosination cy...
The NF-κB signaling pathway is known to play an important role in the regulation of osteoclastic bone resorption and cancer cell growth. Previous studies have shown that genetic inactivation of IκB kinase (IKK), a key component of NF-κB signaling, inhibits osteoclastogenesis, but the effects of pharmacologic IKK inhibitors on osteolytic bone metastasis are unknown. Here, we studied the effects ...
Parthenolide is a naturally occurring terpene with promising anticancer properties, particularly in the context of acute myeloid leukemia (AML). Optimization of this natural product has been challenged by limited opportunities for the late-stage functionalization of this molecule without affecting the pharmacologically important α-methylene-γ-lactone moiety. Here, we report the further developm...
The NF-kappaB signaling pathway is known to play an important role in the regulation of osteoclastic bone resorption and cancer cell growth. Previous studies have shown that genetic inactivation of IkappaB kinase (IKK), a key component of NF-kappaB signaling, inhibits osteoclastogenesis, but the effects of pharmacologic IKK inhibitors on osteolytic bone metastasis are unknown. Here, we studied ...
Hypermethylation of 5'-cytosine-guanosine islands of tumor suppressor genes resulting in their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA methylation with DNA methylation inhibitors has been shown to result in cancer cell differentiation or apoptosis and represents a novel strategy for chemotherapy. Currently, effective DNA methylation inhibitors are mainl...
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