Background Primary solid tumor metastasis to the spleen is a rare event, and often presents as an incidental finding without clinical symptoms of the patient. The most common primary tumors that metastasize to the spleen are colorectal, ovarian, and lung carcinomas. Parotid tumor metastasis to the spleen is extremely rare. We report an unusual case of metastatic parotid adenocarcinoma NOS (not ...

OBJECTIVE Aggressive cutaneous squamous cell carcinoma (cSCC) patients are at increased risk of metastasis. Currently, there are no accepted criteria or biomarkers for reliably predicting individuals at risk for recurrence and metastasis. Our objective is to determine if pS6 and pERK can predict cSCC aggressiveness and to identify primary tumor characteristics that may predict parotid metastasi...

BACKGROUND Surgery for benign parotid tumors has undergone several evolutionary steps over the past century. Prior to the 1930s, the focus of parotid surgery was to limit the risk of facial nerve paralysis, which made intracapsular enucleation the most common procedure performed. However, it became widely recognized that the postoperative risk of recurrence was unacceptably high, even for benig...

The Warthin’s tumor or papillary cystadenoma lymphomatosum is a benign neoplasm which affects commonly the salivary glands und especially the parotid gland. We present a case of an 80-year-old Caucasian woman, who presented in our ENT department because of a progressive swelling in the left parotid gland. The clinical as well as the radiological findings suggested a multifocal lobular neoplasia...

The interaction between tumor cells and surrounding normal cells is very important in the prognosis of tumors. The object of this study was to determine the effect of recipient bed of tumor xenograft on tumor metastasis using a novel parotid gland tumor model. HeLa cells were xenografted into the parotid gland or subcutaneous tissues of athymic mice. Eight weeks after the transplantation, all m...

Warthin’s tumor, cystadenolymphoma, papillary cytoadenoma lymphomatomsum and adenolymphoma are all different terminology of the same pathology. Warthin’s tumor is a benign salivary gland tumor arises almost exclusively in intraor periparotid lymphoid stroma and represents 5-8% of all salivary gland tumors. It accounts for 8-12% of all benign tumors affecting the parotid gland, and ranks as the ...

Sialadenoma papilliferum is a rare benign salivary gland tumor. We present an unusual case of sialadenoma papilliferum of the parotid gland, discuss clinical presentation, diagnostic challenges, and review of the literature. A 65-year-old male smoker presented with a large, exophytic, fungating, painless mass in the tail parotid for 8 years. The tumor developed an exophytic component 2 years be...

BACKGROUND Our objective was to evaluate the outcome of patients treated for squamous cell carcinoma (SCC) of the parotid gland. METHODS We conducted a retrospective chart review of the tumor registry from 1982 through 2003 at a tertiary referral medical center. Patients with SCC of the parotid gland were identified and followed for a minimum of 2 years after therapy. RESULTS SCC involving ...

Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that usually develops in the pleura and peritoneum. The head and neck region is involved in only 6% of the cases. Involvement of the parotid gland is a rare phenomenon, with only 24 cases reported in the literature. The aim of this study is to report an additional case of SFT affecting the parotid gland, and to review the literature o...