Osteoporosis is increasingly found in the elderly and senile, maintaining its enormous medical social significance. The effect of hormones on bone metabolism beyond doubt. However, currently data sex tissue prevails. As for other hormones, sometimes, there are conflicting opinions. aim study: Based published data, to study contribution endocrine system development osteoporosis elderly. Material...

Next to smoking, obesity is the second leading preventable risk factor for cancer, but increasing rates of and overweight are estimated overtake smoking as cancer factor. Few research studies have investigated dysregulated endocrine metabolism dietary phosphate a potential mediating in association with cancer. Phosphate toxicity, accumulation excess body from metabolism, associated tumorigenesi...

CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). PTH acts to stimulate a rapid increment in serum calcium and has a crucial role in calcium homeostasis. Major target organs of PTH are kidney and bone. The oversecretion of the hormone results in hype...

We examined the contribution of the primary hormones of calcium homeostasis to the control of calcium intake in the rat. Male Sprague-Dawley rats with 50 mM CaCl2 solution as their only source of calcium received subcutaneous hormone infusions for 13 days. Parathyroid hormone (PTH; 40, 80, or 160 ng/h) produced sustained dose-related decreases in CaCl2intake. High doses of calcitonin (CT; 32 or...

In endocrine glands, vigorous and coordinated responses are often elicited by modest changes in the concentration of the agonist molecule. The mammalian parathyroid gland is a representative case. Small (5%) changes in serum calcium result in 10-fold (1,000%) changes in glandular parathyroid hormone (PTH) release. In vitro, single isolated cells are observed to secrete fewer hormones than cells...

Background. Hyperparathyroidism is underdiagnosed in pregnancy, yet early diagnosis is necessary for the potentially severe sequelae of hypercalcemia for both the woman and fetus. Case. A 31-year-old, gravida 3, para 0-0-2-0 at 32 weeks and 3 days of gestation, presented with preeclampsia with severe features concomitant with acute pancreatitis and known diabetes mellitus type 2. She was stabil...

abstract parathyroid adenoma is a benign tumor of the parathyroid glands. the cause of most parathyroid adenomas is unknown. parathyroid adenoma increases the secretion of parathyroid hormone and results in primary hyperparathyroidism. high amounts of parathyroid hormone in the blood cause the imbalance of calcium, which leads to various complications such as kidney stones, depression, lethargy...

Blood-brain barrier dysfunction characterised by brain parenchymal extravasation of plasma proteins may contribute to risk of neurodegenerative disorders, however the mechanisms for increased capillary permeability are not understood. Increasing evidence suggests vitamin D confers central nervous system benefits and there is increasing demand for vitamin D supplementation. Vitamin D may influen...

The importance of the seasonal variation of calcitropic hormones to growing skeleton has not been established. We studied whether there exists a seasonal variation in calcitropic hormones, bone mineral density (BMD) and bone remodelling markers in early puberty girls. One hundred and ninety-six girls, mean age 11.4 (sd 0.4) years, in Tanner stage 2 (early puberty) and 3 (mid-puberty) were studi...