Introduction: Currently, the integrated data regarding prevalence of gastrointestinal parasitic infections in Central Java is still lacking particularly, Simo district which considered to have second lowest percentage clean and healthy living habits (60.25%) Boyolali Regency. Therefore, an estimation intestinal protozoan helminth are crucial order formulate a proper community intervention espec...

Intestinal parasite infections are still prevalent in developing countries and Cameroon where over 90% of the population is at high risk. To assess distribution intestinal parasitic risk factors city Yaoundé, both household parasitological surveys were conducted from October to December 2019 among inhabitants lowlands aged 15 years over. Stools samples collected screened for parasites presence ...

Environmental fluctuations can select for generalism, which is also hypothesized to increase organisms' ability to invade novel environments. Here, we show that across a range of temperatures, opportunistic bacterial pathogen Serratia marcescens that evolved in fluctuating temperature (daily variation between 24°C and 38°C, mean 31°C) outperforms the strains that evolved in constant temperature...

Intracellular parasitic protozoans of the genus Leishmania depend for their survival on the elaboration of enzymic and other mechanisms for evading toxic free-radical damage inflicted by their phagocytic macrophage host. One such mechanism may involve superoxide dismutase (SOD), which detoxifies reactive superoxide radicals produced by activated macrophages, but the role of this enzyme in paras...

We describe the design, synthesis and biological evaluation of conformationally-locked 5'-acyl sulfamoyl adenosine derivatives as new parasitic inhibitors against Trypanosoma and Leishmania. The conformationally-locked (3'-endo, North-type) nucleosides have been synthesized by covalently attaching a 4'-CH(2)-O-2' bridge () across C2'-C4' of adenosine in order to reduce the conformational flexib...

Leishmania donovani and Leishmania braziliensis grown in culture formed millimolar concentrations of allopurinol ribonucleoside 5'-monophosphate from [6-14C]allopurinol. In addition, allopurinol 1-ribonucleoside, oxipurinol riboside 5'-monophosphate, and three new metabolites of allopurinol, namely, 4-aminopyrazolo(3,4-d)pyrimidine ribonucleoside 5'-monophosphate and the corresponding di- and t...

Progesterone (P4) plays different physiological roles, including reproductive and non-reproductive actions. Most of P4 effects are mediated by its interaction with its nuclear receptor (PR). Among the non-reproductive functions of P4, the regulation of the immune response, particularly during pregnancy, is remarkably important. P4 is able to modulate the immune response during normal physiologi...

Intestinal parasitic infections can significantly contribute to the burden of disease, may cause nutritional and energetic stress, and negatively impact the quality of life in low income countries of the world. This cross-sectional study done in Mwea irrigation scheme, in Kirinyaga, central Kenya, assessed the public health significance of soil-transmitted helminthiases (STH), schistosomiasis, ...