Bachground: Paraquat (PQ) intoxication manifests with pulmonary edema and fibrosis, heart failure, hepatic failure, and sometimes convulsions. In severe cases, the patients may die within the early hours. At best conditions, the conventional therapeutic methods can only save less than 50% of the victims of intentional PQ intoxication. The aim of this study was to evaluate the outcome of new t...

results the results reveal that pq can decrease mitochondrial viability, deplete gsh content, increase mitochondrial ros formation, and enhance lpo and mitochondrial membrane damage. the pretreatment of mitochondria with ng has the ability to reduce the toxic effects of pq in isolated mitochondria. background paraquat (pq) is a dipyridyl herbicide that sustains damage due to redox cycling. an i...

Paraquat (PQ) is a highly toxic herbicide, which not only leads to acute organ damage, but also to a variety of complications. Patients with severe PQ-induced poisoning may succumb to multiple organ failure involving the circulatory and respiratory systems. Although numerous studies have been performed investigating PQ poisoning, cases of extreme bradycardia caused by acute PQ-induced poisoning...

Exposure to environmental risk factors such as herbicides in early life has been proposed to play important roles in the development of neurodegenerative disorders in adult life. To test this hypothesis, we used a zebrafish model to link the herbicide paraquat (PQ) to disease etiology. Strikingly, treatment of 18 hpf embryonic zebrafish with low-dose PQ treatment (0.04 ppm, lower than the accep...

Paraquat (PQ) toxicity involves the generation of the superoxide anion, which can lead to the formation of more toxic reactive oxygen species. The purpose of this study was to investigate the effect of PQ on biochemical parameters in male rats and possible role of omega 3 fatty acids (ω3) and selenium (Se). The animals were divided randomly into 4 groups and kept at 10 rats per group. The first...

ABSTRACT Cyanide (KCN) and paraquat (PQ) are very toxic to mitochondria. In this study the toxicity of KCN and PQ in the isolated rat liver mitochondria was determined using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and JG-B (Janus green B) assay by multiwell scanning spectrophotometry. JG-B was used not only for the vital staining of mitochondria, but also fo...

Paraquat (PQ) is an agrochemical agent commonly used worldwide, which is allied to potential risks of intoxication. This herbicide induces the formation of reactive oxygen species (ROS) that ends up compromising various organs, particularly the lungs and the brain. This study evaluated the deleterious effects of paraquat on the central nervous system (CNS) and peripherally, with special attempt...

Paraquat is a commonly used herbicide in many countries which can lead to systematic poisoning on exposure, In this study, paraquat (PQ)-induced changes in the expression of Cyclooxygenase-2 (COX-2) along with biochemical and histopathological changes in the lungs, liver and kidneys were studied. Twenty four male Wistar rats (180-200 g) were exposed either against saline as control group or var...

The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress devel...