paragangliomas are neoplasms of neural crest origin. in the head and neck, they uncommonly involve the larynx. the distinction between paragangliomas and other neuroendocrine tumors can be difficult. precise diagnosis is important in order to optimize patient treatment. diagnosis relies mostly on histopathologic examination followed by immunohistochemistry. here we report a 77-year-old woman wi...

Paragangliomas are neuroendocrine tumors arising from the extra-adrenal sympathetic or parasympathetic nervous system,1 either from the chromaffin-positive paraganglionic tissue or the chromaffin-negative glomus cells2 derived from the embryonic neural crest. They are localized in either the head and neck, thorax, or abdominal area, and they are usually benign but can occasionally show malignan...

Pheochromocytoma arising from outside the adrenal glands is also called paraganglioma. When it occurs below the diaphragm, in the organ of Zuckerkandl or retroperitoneum, it is also called extra-adrenal pheochromocytoma. Paragangliomas are rare tumors which arise from neuroendocrine cells and extra-adrenal paragangliomas (EAPs) account for only 10-15% if all paragangliomas and may present incid...

Paragangliomas are extra-adrenal counterparts of pheochromocytomas and are found at various anatomical sites such as the retroperitoneum, mediastinum, jugular foramen and carotid bifurcation, the latter two fonns being coined as chemodectomas. The vertebral column, especially the llUllbar zone, is one of the rarest sites to be involved by paragangliomas. These lesions may have secretory fun...

BACKGROUND Hereditary head and neck paragangliomas (HNP) are very often associated with pheochromocytoma-paraganglioma syndromes, which are caused by mutations in genes encoding subunits of succinate dehydrogenase (SDHx) complex. The aim of this study was to determine the frequency and location of HNP among SDHx carriers. MATERIAL/METHODS A total of 72 patients with SDHx mutations underwent c...

Paragangliomas are neural crest-derived tumors, arising either from chromaffin sympathetic tissue (in adrenal, abdominal, intra-pelvic, or thoracic paraganglia) or from parasympathetic tissue (in head and neck paraganglia). They have a specific cellular metabolism, with the ability to synthesize, store, and secrete catecholamines (although most head and neck paragangliomas do not secrete any ca...

Background: Paragangliomas (PGLs) are neuroendocrine tumors that arise from the neuroepithelial cell group called paraganglia. Spinal paragangliomas (SPs) are extremely rare, most of which are observed as intradural tumors in the cauda equine, the filum terminale, and the lumbosacral region, but rarely in the thoracic region. We aimed to study the clinical, radiographic and pathologic character...

Most of the tumors (85-90%) arise in the adrenal medulla, and the tumors are denoted as pheochromocytomas. Extra-adrenal paragangliomas account for the remaining 10-15% of lesions and can be found in practically every site of the normal paraganglia (1-3). Thoracic paragangliomas constitute only 1-2% of all paragangliomas and the tumors are mostly found in the mediastinal compartment (2). A meta...