A hallmark of polarized cells is the segregation of the PAR polarity regulators into asymmetric domains at the cell cortex1,2. Antagonistic interactions involving two conserved kinases, atypical protein kinase C (aPKC) and PAR-1, have been implicated in polarity maintenance1,2, but the mechanisms that initiate the formation of asymmetric PAR domains are not understood. Here, we describe one pat...

We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore the pathophysiological functions of these receptors. In this report, we evaluated mean arterial pressure and heart rate (HR) changes in response to PAR-1 or PAR-2 activation in anesthetized wild-type (WT), PAR-1-deficient (PAR-1(-/-)), and PAR-2-deficient (PAR-2(-/-)) mice. In WT mice, TFLLRNPNDK, a PAR-1 s...

Processing graphical data, either for its editing or the synthesis of new content, demands agood balance between the different sources of information one may exploit. Unlike "proce-dural" techniques, synthesis by example stands out thanks to its extreme ease-of-use : indeed,tasks such as identification, analysis and reproduction of the distinguishing features of the user-provide...

ion de prédicats L’abstraction de prédicats peut être utilisée pour améliorer l’analyse d’accessibilité. Elle consiste à analyser la valeur de vérité d’un ensemble de prédicats plutôt que de calculer des ensembles d’état continus [6, 5]. Des techniques de raffinement guidées par les contre-exemples [30] sont une autre application importante de cette approche. Ces techniques ont été utilisées da...

Extravascular activation of the coagulation cascade in the lung is commonly observed in pulmonary fibrosis. Coagulation proteases may exert profibrotic cellular effects via protease-activated receptors (PARs)-1 and -2. Here, we investigated the potential role of two other members of the PAR family, namely PAR-3 and PAR-4, in the pathobiology of lung fibrosis. Elevated expression of PAR-3, but n...

The coagulation and fibrinolytic systems contribute to malignancy by increasing angiogenesis, tumor growth, tumor invasion, and tumor metastasis. Oncogenic transformation increases the expression of tissue factor (TF) that results in local generation of coagulation proteases and activation of protease-activated receptor (PAR)-1 and PAR-2. We compared the PAR-dependent expression of urokinase pl...

radio frequency identification (rfid) is used to identify the characteristics of an object wirelessly using radio waves. the purpose of this technology in this study is mainly focused on healthcare for inventory management and theft control replacing the manual logs. the storage and tracking of high-cost inventory items is developed. automatic reordering and billing interfaces are designed for ...

Trypsin and thrombin activate proteinase-activated receptors (PARs), which modulate gastrointestinal motility. The common bile duct is exposed to many proteinases that can activate PARs, especially during infection and stone obstruction. We investigated PAR effects on common bile duct motility in vitro. Contraction and relaxation of isolated guinea pig common bile duct strips caused by PAR(1), ...