BACKGROUND & AIMS Basic research aimed at a better understanding of pancreatic carcinogenesis and improving the treatment of this disease is crucial because the majority of pancreatic cancers are highly aggressive and therapeutically nonaccessible. Cyclooxygenase (COX)-2, which is a key enzyme of prostaglandin (PG) biosynthesis, is overexpressed in around 75% of human carcinomas including those...

Cystic neoplasms of the pancreas are relatively rare, comprising 10 percent of pancreatic cysts and only 1 percent of pancreatic cancers. Cystic neoplasms include mucinous cystic neoplasms, serous cystadenomas, papillary cystic tumors, cystic islet cell tumors and intraductal papillary mucinous neoplasms of the pancreas (IPMNs). IPMN was first described in 1982. It has been most commonly descri...

differential diagnosis a need when cystic profile lesions are found in the pancreas (1,2). And of course intraductal papillary mucinous neoplasm of the pancreas must be carefully assessed in the differential diagnosis of such lesions. For every finding that is cystic in nature a first step is always to tell tumors, whether benign or malignant, from non-neoplastic conditions. To consider a cysti...

INTRODUCTION Canine ovarian tumours are divided into 3 groups depending on their origin; germ cell tumours, sex-cord stromal tumours and epithelial cell tumours. Germ cell tumours include dysgerminomas, teratomas and embryonal carcinomas. Stromal tumours include granulosa-theca cell tumours, thecomas and luteomas. Epithelial neoplasms make up about 40–50 % of all ovarian growths and originate f...

Note Warthin's tumor is the second most common benign salivary gland tumor, which is located almost exclusively in the parotid gland. Warthin's tumor accounts for about 15% of all epithelial tumors of the parotid gland. The initial description of the tumor goes back to Hildebrand in 1895, who considered this disease a variant of congenital epithelial cyst of the neck. In 1910, Albrecht and Arzt...

It is presently not clear if ovarian carcinomas arise de novo or from benign precursors (cystadenomas) and if high-grade malignant tumors (carcinomas) develop from preexisting low-grade carcinomas. The presence of allelic losses on chromosome 11p15.5 distinguishes high-grade ovarian carcinomas from either low-grade carcinomas or cystadenomas. We therefore examined the distribution of such losse...

PURPOSE Ovarian carcinomas are believed to arise de novo from surface epithelium, but the actual molecular pathogenesis is unknown. The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis. EXPERIMENTAL DESIGN We analyzed the DNA promoter methylation status of eight tumor...