In previous publications 2,3) authors reported the preventive effect of riboflavin, choline, pantothenic acid and vitamin A on the occurrence of blood hypertension induced by the high salt diet. The present report concerns the results of the investigation of excretion of sodium in urine, sodium content of various tissues together with the pantothenic acid content in liver of rats fed high salt ...

The compounds /3-d-pantoylaminoethanethiol (PAET) and the corresponding disulfide had been prepared by Barnett (1) in an attempt to find substances similar in structure to pantoyltaurine but more favorable in their inhibitory action on pantothenic acid-requiring microorganisms. Barnett showed that, although the compounds did inhibit the growth of Lactobacillus arabinosus to about the same exten...

Underkofler et al. (1943) first demonstrated that pantothenic acid is an essential requirement for Acetobacter suboxydans, ATCC 621, and that this organism responds to pantolactone in a pantothenate deficient medium. j5-Alanine, however, is not able to replace pantothenic acid. Subsequently, Sarett and Cheldelin (1945) described the assay of pantolactone using the same strain of A. suboxydans. ...

Experiments using the Warburg-Barcroft apparatus led to the following results and conclusions: (1) Two yeasts in three different media were strikingly stimulated in their respiration by minute amounts of pantothenic acid. (2) Nine other compounds (vitamins and other biologically important substances) were tested and found in all cases to have on the deficient G.M. yeast, lesser and in some case...

Pantothenic acid, discovered by Dr. R. J. Williams, has been shown to stimulate the growth of a number of strains of yeast (1). The amount of the stimulation depended on the strain of yeast used and some of the yeasts grew still more rapidly when inosite or crystalline vitamin B, or both were also present in the culture medium (2). Dr. Williams has generously shared with me some of the pantothe...

INTRODUCTION The purpose of this study was to determine the safety, tolerability and effectiveness of daily administration of an orally administered pantothenic acid-based dietary supplement in men and women with facial acne lesions. METHODS A randomized, double-blind, placebo-controlled study of adults previously diagnosed with mild to moderate acne vulgaris was performed. Subjects were rand...

Vitamin B5 was isolated from yeast in 1933, and a few years later from liver, by R.J. Williams. The main role of pantothenic acid in cells is the synthesis of coenzyme A, as well as the synthesis and metabolism of proteins, carbohydrates and fats. Regarding the human body, this compound is involved in the health of the digestive, nervous, circulatory, and skeletal systems, skin and hair, as wel...

The amino acid beta-alanine is an intermediate in pantothenic acid (vitamin B(5)) and coenzyme A (CoA) biosynthesis. In contrast to bacteria, yeast derive the beta-alanine required for pantothenic acid production via polyamine metabolism, mediated by the four SPE genes and by the FAD-dependent amine oxidase encoded by FMS1. Because amine oxidases generally produce aldehyde derivatives of amine ...