BACKGROUND Self-report instruments for the assessment of depressive symptoms in patients with psychotic disorders are scarce. The Quick Inventory of Depressive Symptoms (QIDS-SR16) may be a useful self-report instrument, but has received little attention in this field. This paper aimed to test the psychometric properties of the QIDS-SR16 questionnaire in patients with a psychotic disorder. ME...

There are diverse studies which afford evidences that risperidone is as effective second generation antipsychotics in treating positive symptoms and more treatment of negative symptoms. This study intended to find the clinical efficacy safety profile lurasidone comparing with risperidone, a drug common use nowadays. Patients aged between 18 60yrs, new onset who fulfil ICD-10 criteria for primar...

background: the purpose of this study was to test the hypothesis that the addition of buspirone, a partial agonist of 5ht1a receptor, to ongoing treatment with typical antipsychotics would improve the positive and negative symptoms in patients with chronic schizophrenia. materials and methods: in this study, 50 patients including 40 male and 10 female were recruited with chronic schizophrenia w...

Objectives. We aimed at evaluating both the efficacy and safety of TJ-54 (Yokukansan) in patients with treatment-resistant schizophrenia. This randomized, multicenter, double-blind, placebo-controlled study was conducted. Methods. One hundred and twenty antipsychotic-treated inpatients were included. Patients were randomized to adjuvant treatment with TJ-54 or placebo. During a 4-week follow-up...

BACKGROUND This study identified subgroups of patients with schizophrenia who differed on their movement disorder profile and compared their treatment outcomes. METHODS Data from a randomized, open-label, one-year study of patients with schizophrenia who were treated with antipsychotics in usual clinical care settings were analyzed (n = 640). Five measures of movement disorder were incorporat...

objective : poor premorbid adjustment has been reported to be a predictor of more severe psychotic symptoms and poor quality of life in such psychotic disorders  as  schizophrenia.  however,  most  studies  were  performed  on chronic schizophrenic patients, and proposed the likelihood of recall biases and the effect of chronicity.  the aim of this study was to investigate these factors in a sa...

BACKGROUND/AIM There is a high rate of schizophrenic patients who do not adhere to their prescribed therapy, despite the implementation of antipsychotic long-acting injections and the introduction of atypical antipsychotics. The aim of this study was to investigate the differences in sociodemographic, clinical and medication adherence variables between the two groups of schizophrenic patients o...

OBJECTIVE This retrospective case series study of the effectiveness of electroconvulsive therapy (ECT) augmentation on clozapine-resistant schizophrenia was conducted by EMR review. METHODS Clozapine-resistance was defined as persistent psychotic symptoms despite at least 12 weeks of clozapine administration with blood levels over 350 ng/mL in order to rule out pseudo-resistance. Seven in-pat...

Introduction Olanzapine (OLA) is a common first-prescribed antipsychotic and has shown favorable efficacy in acutely exacerbated patients with schizophrenia. The mixed receptor activity of OLA its greater affinity for serotonin 5-HT2A rather than dopamine D2 receptors are similar to those clozapine. Pharmacokinetically, metabolized mainly by hepatic cytochrome enzyme P450 1A2 (CYP1A2). Because ...