نتایج جستجو برای: panel reactive antibody
تعداد نتایج: 396266 فیلتر نتایج به سال:
FTY720, a novel immunomodulator, causes rapid temporary depletion of peripheral-blood lymphocytes, inducing their sequestration in secondary lymphoid organs. FTY720 is effective in animal models of transplantation and is under evaluation for use in human transplantation. We report a 48-year-old renal transplant recipient who developed acute antibody-mediated rejection under a high-dose FTY720 (...
Flow cytometric crossmatching (FCXM) and panel reactive antibody (PRA) screening techniques are more sensitive than anti-human globulin enhanced cytotoxicity (AHG-CDC) techniques at detecting anti-HLA antibodies. The clinical significance of a positive FCXM in primary renal transplant recipients with a negative AHG-CDC crossmatch is unclear. We performed retrospective FCXM and flow cytometric p...
Single-antigen bead (SAB) testing permits reassessment of immunologic risk for kidney transplantation. Traditionally, high panel reactive antibody (PRA), retransplant and deceased donor (DD) grafts have been associated with increased risk. We hypothesized that this risk was likely mediated by (unrecognized) donor-specific antibody (DSA). We grouped 587 kidney transplants using clinical history ...
Our previous preclinical studies and a Phase I clinical trial DP6-001 have indicated that a polyvalent Env formulation was able to elicit broadly reactive antibody responses including low titer neutralizing antibody responses against viral isolates of subtypes A, B, C and AE. In the current report, a panel of 62 gp120 immunogens were screened in a rabbit model to identify gp120 immunogens that ...
مقدمه: آنتی‌بادی‌های ضد آنتی‌ژن‌های سازگاری بافتی (HLA) طی آلوایمونیزاسیون به دنبال انتقال خون، حاملگی و یا پیوند اعضاء تولید می‌شوند. این آنتی‌بادی‌ها در سقط دخالت دارند و در افراد سالم غیرآلوایمونیزه نیز گزارش شده‌اند. آنتی‌بادی‌های ضد HLA منجر به برخی عوارض انتقال خون می‌شوند، لذا مطالعه حاضر با هدف بررسی فراوانی آنتی‌بادی‌های مذکور در اهداءکنندگان خون با تمرکز بر زنان (با و بدون سابقه حاملگ...
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