Plasma concentrations of pancuronium were measured in nine patients undergoing surgery because of total biliary obstruction. When compared with the averaged model-independent pharmacokinetic parameters obtained for normal patients, the terminal half-life of 270 min was more than twice normal (132 min, P less than 0.001); the plasma clearance of 59 ml min-1 was less than half the normal rate for...

PURPOSE To characterize the electromyographic activity of abdominal striated muscles during micturition in urethane-anesthetized female mice, and to quantitatively evaluate the contribution of abdominal responses to efficient voiding. METHODS Cystometric and multichannel electromyographic recordings were integrated to enable a comprehensive evaluation during micturition in urethane-anesthetiz...

Aim: To assess the effect of Omeprazole at neuromuscular junction with and without Pancuronium. Study design: Experimental randomized control study. Place duration study: Department Pharmacology, Islamic International Medical College, Rawalpindi from October 2018 to September 2019 Methods: In this experimental study both a student’s oscillograph cumulative dosage response curve were used record...

The introduction of new anaesthetic drugs demands that their action should be compared with that of already established agents. Pancuronium bromide was introduced into clinical anaesthetic practice by Baird and Reid (I967), and has since achieved widespread acceptance because it is reputed to have fewer cardiovascular side-effects than other non-depolarizing relaxants (Baird, I968; Sellick, 197...