UNLABELLED Awareness of cancer therapy-induced toxicities is important for all clinicians treating patients with cancer. Cancer therapy has evolved to include classic cytotoxic agents in addition to newer options such as targeted agents and catheter-directed chemoembolisation. Several adverse affects can result from the wide array of treatments including effects on the liver, pancreas, and bili...

Abstract Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85% of differentiated cancers. A small percentage PTC variants are considered more aggressive, such as tall cell variant associated with V600E mutation in BRAF gene and rarer columnar variant, which described only 0.2% cases has a poor prognosis. Although locoregional metastases to neck lymph nodes c...

OBJECTIVE Cigarette smoking has been recognized as an important risk factor for pancreas cancer, but the magnitude of the association may vary among geographical areas. Therefore, we reviewed epidemiologic studies on the association between cigarette smoking and pancreas cancer in the Japanese population. METHODS Original data were obtained from MEDLINE searched using PubMed or from searches ...

Introduction. Sensitive and specific imaging of pancreas cancer are necessary for accurate diagnosis, staging, and treatment. The vast majority of pancreas cancers express the carbohydrate tumor antigen CA19-9. The goal of this study was to determine the potential to target CA19-9 with a radiolabeled anti-CA19-9 antibody for imaging pancreas cancer. Methods. CA19-9 was quantified using flow cyt...

The Aim . Study of a clinical case metachronous primary multiple cancer the head pancreas and liver. Materials methods work was carried out with modern domestic foreign literature sources devoted to problem malignant neoplasms. A retrospective analysis patient’s anamnestic data performed, necessary medical documentation studied. Results In 2011, pancreatoduodenal resection performed on patient ...

Solid pseudopapillary tumor (SPT) of the pancreas is one of the most uncommon histotypes of all exocrine pancreatic neoplasms. Disorganization of E-cadherin and β-catenin mutations, two key components of the Wnt signal transduction pathway, has been implicated in the development of SPT, but not other pancreatic tumors. Loss of E-cadherin/β-catenin proteins and tyrosine phosphorylation of E-cadh...

CONTEXT We report a rare case of a repeated pancreatic resection in the remnant distal pancreas 18 months after a Whipple R0 procedure. CASE REPORT In September 2003, a 63-year-old man underwent a Whipple procedure with an extended lymphadenectomy, portal vein resection and direct reconstruction for pancreatic cancer. In September 2004, the tumor marker level increased and MR revealed a tumor...

The molecular basis of pancreatic cancer is not understood. Previous attempts to determine the specific genes expressed in pancreatic cancer have been hampered by similarities between adenocarcinoma and chronic pancreatitis. In the current study, microarrays (Affymetrix) were used to profile gene expression in pancreatic adenocarcinoma (10), pancreatic cancer cell lines (7), chronic pancreatiti...

The molecular basis of pancreatic cancer is not understood. Previous attempts to determine the specific genes expressed in pancreatic cancer have been hampered by similarities between adenocarcinoma and chronic pancreatitis. In the current study, microarrays (Affymetrix) were used to profile gene expression in pancreatic adenocarcinoma (10), pancreatic cancer cell lines (7), chronic pancreatiti...