Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfoni...

Interferons (IFN) are cytokines which, upon binding to cell surface receptors, trigger a series of downstream biochemical events including Janus Kinase (JAK) activation, phosphorylation Signal Transducer and Activator Transcription protein (STAT), translocation pSTAT the nucleus transcriptional activation. Dysregulated IFN signalling has been linked cancer progression auto-immune diseases. Here...

psychological disorders such as depression have more prevalence in inflammatory bowel disease patients and can exacerbate the clinical course of the disease, so anti-depressant therapy may have a potential to positively impact the disease course. on the other hand several antidepressant drugs have shown anti-inflammatory and immunomodulatory properties. thus, this study aimed to explore the ben...

Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfoni...

Introduction: Ulcerative colitis is a chronic inflammation of the large intestine (colon). In patients with ulcerative colitis, ulcers and inflammation of the inner lining of the colon lead to symptoms such as abdominal pain, diarrhea, and rectal bleeding. Previous studies have shown that Matricaria recutita L. have a series of physiological effects for example spasmolytic, carminative, anti...

cytomegalovirus (cmv) infection can cause colitis which is usually manifested with fever, weight loss, anorexia and abdominal pain.watery diarrhea can be the only manifestation. cmv colitis usually can not be diagnosed according to the clinical findings. moreover, endoscopic appearance can exactly mimic pseudo-membranous colitis. here by, we are presenting a patient with fever and watery diarrh...

Since the ordinary tests for diagnosis chronic amebic colitis looks to be unsufficient. We try to design the following study. Our study seeks the importanc.;e of "IFA" (Indirect Immuno Fluorescent Aniti body). Among 145 patients with amebic colitis Entamoeba hystolitica observed with reapeted and specified tests. In searh of serologic tests, antibody range in 20 patients who had amebic coliti...

Polyacrylonitril (PAN)-supported chitosan (CS) nanocomposite membranes were prepared by cross-linking the CS with 3-aminopropyl-triethoxysilane (APTEOS) via sol-gel method. Pervaporative performances of the CS-SiO2/PAN membrane for dehydration of aqueous alcohol solutions were investigated. From SEM cross-sectional images of the membrane, the spongy pores and the finger-like pores we...