© 2009 The Authors. doi: 10.2340/00015555-0644 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Bullous pemphigoid (BP) is the most frequent autoimmune bullous disorder. BP is associated with anti bodies to two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230 (1). The disorder usually affects elderly people, and severe pruritus is typically present. In the...

dermatitis or bacterial and mycological infections (1). BTXA has been used recently to treat focal hyperhidrosis (gustatory sweating, palmo-plantar and axillary hyperhidrosis) (4, 5). There are no data available for the treatment of stump hyperhidrosis. We used BTXA for stump hyperhidrosis in a dosage comparable to that used in palmar hyperhidrosis, i.e. 100 U of Botox. The treatment was very e...

As well as other Multikinase Inhibitors (MKI), Imatinib has been related to cutaneous adverse reactions. The majority of these seem to directly depend on its mechanism of action, namely the inhibition of the physiologic function of cutaneous protein kinases, and appear to be dose dependent. Like other traditional chemotherapy agents, MKI cause alopecia, mucositis and xerosis. Cutaneous findings...

Tinea nigra is a rare superficial mycosis caused by Hortaea werneckii. This infection presents as asymptomatic brown to black maculae mostly in palmo-plantar regions. We performed scanning electron microscopy of a superficial shaving of a tinea nigra lesion. The examination of the outer surface of the sample showed the epidermis with corneocytes and hyphae and elimination of fungal filaments. T...

Clericuzio-type poikiloderma with neutropenia (PN) is characterized by poikiloderma, non-cyclic neutropenia, recurrent sinopulmonary infections, pachyonychia, and palmo-plantar hyperkeratosis. Mutations in the C16orf57 gene, which is located on chromosome 16q13, have been identified as the cause of PN. PN was first described by Clericuzio in Navajo Indians. Herein, we reported the clinical pres...

Dominant GJB2 mutations are known to cause a syndromic form of sensorineural hearing loss associated with palmo-plantar skin manifestations. We present the genotype/phenotype correlations of a new GJB2 mutation identified in three generations of an Italian family (proband, mother and grandfather) whose members are affected by sensorineural hearing impairment associated with adult-onset palmopla...