Background: Increased physical activity is a cornerstone of type 2 diabetes prevention. Perception of a need to change is considered essential in behaviour change process. However, existing literature on perceived need to change health behaviour is limited. In order to broaden the understanding of diabetes prevention by increased physical activity levels (PAL), we assessed factors associated wi...

Background Palbociclib (PAL), a novel small-molecule inhibitor of cyclin-dependent kinases 4 and 6 for the treatment of advanced breast cancer, has demonstrated significant efficacy in prolonging progression-free survival when added to existing therapies. Considering the high cost of PAL, we assessed cost-effectiveness of adding PAL to usual care in treatment of advanced breast cancer. Method...

Glucuronidation is an important pathway in the metabolism of protocatechuic aldehyde (3,4-dihydroxybenzaldehyde, PAL). However, the metabolites and primary UDP-glucuronosyltransferase (UGT) isozymes responsible for PAL glucuronidation remain to be determined in human. Here, we characterized PAL glucuronidation by human liver microsomes (HLMs), human intestine microsomes (HIMs), and 12 recombina...

In this note we show that the determinant identities obtained by Rezaifar and Rezaee (2007)– [1] and Dutta and Pal (2011)–[2] are straightforward consequences of a general result due to Capelli. © 2015 Elsevier Inc. All rights reserved.

salicylic acid (sa) and methyl jasmonate (meja) as phytohormone regulate synthesis of secondary metabolites in a wide range of plant species thereby accumulation of phenylalanine ammonia lyase enzyme (pal) and accelerate of oxygen free radicals, protein kinas and no production. the present research designed to evaluate effect of sa and meja elicitation on accumulation of phenolic compounds, fla...

OBJECTIVE To evaluate a telephone-based child mental health consult service for primary care providers (PCPs). DESIGN Record review, provider surveys, and Medicaid database analysis. SETTING Washington State Partnership Access Line (PAL) program. PARTICIPANTS A total of 2285 PAL consultations by 592 PCPs between April 1, 2008, and April 30, 2011. INTERVENTIONS Primary care provider-init...

A Sb/palygorskite (PAL) composite was synthesized by a facile solvothermal process and applied in catalytic hydrogenation of p-nitrophenol for the first time. It was found that the Sb nanoparticles with the sizes of 2-5 nm were well dispersed on the fiber of PAL, while partial aggregated Sb nanoparticles with sizes smaller than 200 nm were also loaded on the PAL. The Sb/PAL composite with 9.7% ...

The KH domain protein MEX-3 is central to the temporal and spatial control of PAL-1 expression in the C. elegans early embryo. PAL-1 is a Caudal-like homeodomain protein that is required to specify the fate of posterior blastomeres. While pal-1 mRNA is present throughout the oocyte and early embryo, PAL-1 protein is expressed only in posterior blastomeres, starting at the four-cell stage. To be...

Justification logic is an epistemic framework that provides a way to express explicit justifications for the agent’s belief. In this paper, we present OPAL, a dynamic justification logic that includes term operators to reflect public announcements on the level of justifications. We create dynamic epistemic semantics for OPAL. We also elaborate on the relationship of dynamic justification logics...

The ability of educational games to promote students’ engagement in learning and practice depends on perceived enjoyment of those games. This study investigated high school students’ perceptions and enjoyment of games within the Writing Pal intelligent tutoring system. In accord with research on motivation, results showed that perceived helpfulness and difficulty of the games were the main pred...