AIM To determine whether attention deficit hyperactivity disorder (ADHD) is associated with other prevalent medical pathologies of the paediatric age. DEVELOPMENT Several paediatric pathologies were selected with the aim of reviewing their association with ADHD: in paediatric pulmonology, asthma and other allergic processes; in paediatric neurology, headache and febrile seizures; in paediatri...

1. Vincent Pallotti Hospital and Department of Paediatric Allergy, Red Cross War Memorial Children’s Hospital 2. Department of Paediatric Allergy, Red Cross War Memorial Children’s Hospital 3. Department of Paediatric Radiology, Red Cross War Memorial Children’s Hospital 4. Vincent Pallotti Hospital and Department of Paediatric Surgery, Red Cross War Memorial Children’s Hospital 5. Department o...

The purpose of the workshop was to help inform the EMA and its Paediatric Committee (PDCO) on how to best compose opinions that set out detailed requirements for non-clinical and clinical paediatric studies, to provide for high-quality Paediatric investigation plans (PIPs) for this group of tumours. The objectives were to learn from invited experts about recent scientific translational developm...

The European Paediatric Regulation (EUPR) calls for the fostering of high quality ethical research and medicinal products to be used in children. The EUPR provides the background, goals, and requirements for paediatric clinical trials. Paediatric clinical trials in children are mandatory to generate data on new drugs as well as on drugs used off-label or for unlicensed indications. The Family P...

BACKGROUND Drug development for rare diseases is challenging, especially when these orphan drugs (OD) are intended for children. In 2007 the EU Paediatric Drug Regulation was enacted to improve the development of high quality and ethically researched medicines for children through the establishment of Paediatric Investigation Plans (PIPs). The effect of the EU Paediatric Drug Regulation on the ...

BACKGROUND/AIM While neuron-glia 2 (NG2) is well-characterized in the developing brain and in adult high-grade gliomas, little is known about NG2 expression in paediatric brain tumors. Here, NG2 expression was examined in a range of paediatric brain tumors. MATERIALS AND METHODS A retrospective immunohistopathological analysis of 57 paediatric brain tumor biopsies of various tumor types was c...

Background: Although psychiatric morbidity is common amongst paediatric patients, little is known about the availability of CAMH paediatric liaison services. Method: We surveyed all Trusts with specialist CAMH services and paediatric units in Greater London, enquiring about the nature of liaison that CAMHS provide. Results: We found that although liaison paediatric work was common, dedicated pa...

Oral mucositis (OM) can aggravate the paediatric patients’ clinical condition and elicit multiple debilitating oral symptoms that irrevocably alter patients’ quality of life.1,2 Nonetheless, the full spectrum of pathogenesis and factors in the development of OM remains poorly understood, in particular in the paediatric cancer population. This study aimed to determine the factors associated with...

Practical elective and emergency skills form an essential part of neonatal care. Paediatric trainees should be competent in certain procedures such as intubation and umbilical line placement. These are essential requirements for general paediatric training according to the Royal College of Physicians of Ireland. We sought to determine the current status of postgraduate neonatal procedural skill...

Background:Non-accidental poisoning in the paediatric age group is uncommon and international literature on this subject is limited. There are no Sri Lankan paediatric studies on non-accidental poisoning to date. The objective of the current study was to explore the predisposing factors and profile of children less than 12 years in rural Sri Lanka who had non-accidental poisoning. Method:This c...